IRF: Institutional Repository FHNW
Willkommen auf der Publikations- und Forschungsdatenbank der Fachhochschule Nordwestschweiz FHNW.
Das IRF ist das digitale Repositorium der FHNW. Es enthält Publikationen, studentische Arbeiten und Projekte.
Weitere Informationen finden Sie im IRF-Handbuch.
Bereiche im IRF
Wählen Sie einen Bereich, um in den enthaltenen Sammlungen zu stöbern.
- APS FHNW
- HABG FHNW
- HGK Basel FHNW
- HSI FHNW
- HLS FHNW
- HSM Basel FHNW
- HSA FHNW
- HTU FHNW
- HSW FHNW
- PH FHNW
Neuzugänge
Electrocochleography latency. correlation with electrode position during cochlear implantation
(Lippincott Williams & Wilkins, 10.2025) Andonie, Raphael R.; Wimmer, Wilhelm; Wildhaber, Reto; Mantokoudis, Georgios; Caversaccio, Marco; Weder, Stefan
Objectives:
Cochlear implant (CI) candidates increasingly exhibit some degree of residual hearing, which should be preserved despite the implantation. Today, cochlear health is monitored during CI surgery by tracking the cochlear microphonic (CM) amplitude from intracochlear electrocochleography (ECochG) measurements. However, recent studies indicate that the insertion depth of the measuring electrode must be considered to accurately interpret these signals. The acoustic path from the cochlear base to the apex induces excitation delays in deeper regions, which should be reflected in the CM measurements. In this study, we analyzed the potential of cochlear microphonic latency (CML) as an objective method for continuously tracking CI electrode position during cochlear implantation. In addition, we examined whether CML can be associated with residual hearing.
01A - Beitrag in wissenschaftlicher Zeitschrift
Bryophyllum pinnatum modulation of signaling pathways relevant for preterm labor in human myometrial cells
(Elsevier, 03.2025) Zurfluh, Leonie; Santos, Stefanie; Ruppen, Annina; Mosbacher, Johannes; Haslinger, Christian; Ochsenbein-Kölble, Nicole; Potterat, Olivier; Simões-Wüst, Ana Paula
Preparations of Bryophyllum pinnatum have been used as a well-tolerated treatment of preterm labor, initially in anthroposophic hospitals and, more recently, also in conventional settings. In vitro studies with human myometrial cells have shown that B. pinnatum leaf press juice inhibits both intracellular Ca2 + signaling and the activation of inflammatory pathways induced by the relevant hormone oxytocin. However, the compounds responsible for these inhibitory effects and the potential involvement of related signaling pathways remain unknown. In the present study, we aim to address these knowledge gaps. In vitro experiments were conducted in hTERT-C3 human myometrial cells, using alamarBlue assay, fluorescent intracellular Ca2+ assay, ELISA, proteomics and real-time PCR. Contractility studies were conducted in an ex vivo organ bath model using human myometrial tissue. No single compound from B. pinnatum leaves mimicked the inhibitory effect of the whole leaf press juice on OT-induced Ca2+ signaling. However, a bufadienolide-enriched fraction and the bufadienolides bersaldegenin-1,3,5-acetate, bryophyllin A and bersaldegenin-3-acetate, but not bersaldegenin-1-acetate, reduced OT-induced COX-2 expression and attenuated NFκB activation. That the juice can inhibit prostaglandin F2α-induced contractions was shown in the myometrium bath model. Proteomics analysis revealed that the leaf juice reduced expression of various extracellular matrix proteins. Cell viability assays showed that the various inhibitory effects cannot be attributed to cytotoxicity. Taken together, these results further support investigations on the use of B. pinnatum as a well-tolerated candidate for long-term treatment of preterm labor.
01A - Beitrag in wissenschaftlicher Zeitschrift
Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma
(Nature, 01.08.2025) Miglino, Nicola; Toussaint, Nora C.; Ring, Alexander; Bonilla, Ximena; Tusup, Marina; Gosztonyi, Benedict; Mehra, Tarun; Gut, Gabriele; Jacob, Francis; Chevrier, Stephane; Lehmann, Kjong-Van; Casanova, Ruben; Jacobs, Andrea; Sivapatham, Sujana; Boos, Laura; Rahimzadeh, Parisa; Schuerch, Manuel; Sobottka, Bettina; Chicherova, Natalia; Yu, Shuqing; Wegmann, Rebekka; Mena, Julien; Milani, Emanuela S.; Goetze, Sandra; Esposito, Cinzia; Sarabia del Castillo, Jacobo; Frei, Anja L.; Nowak, Marta; Irmisch, Anja; Kuipers, Jack; Baciu-Drăgan, Monica-Andreea; Ferreira, Pedro F.; Singer, Franziska; Bertolini, Anne; Prummer, Michael; Lischetti, Ulrike; Ak, Melike; Al-Quaddoomi, Faisal S.; Albert, Silvana I.; Albinus, Jonas; Alborelli, Ilaria; Andani, Sonali; Attinger, Per-Olof; Baciu-Drăgan, Monica-Andreea; Baumhoer, Daniel; Beck-Schimmer, Beatrice; Bernasconi, Lara; Bosshard, Lars; Calgua, Byron; Chevrier, Stéphane; Coelho, Ricardo; D’Costa, Maya; Danenberg, Esther; Davidson, Natalie R.; Engler, Stefanie; Erkens, Martin; Eschbach, Katja; Fedier, André; Ficek-Pascual, Joanna; Frey, Bruno; Grob, Linda; Günther, Detlef; Haeuptle, Pirmin; Heinzelmann-Schwarz, Viola; Herter, Sylvia; Holtackers, Rene; Huesser, Tamara; Immer, Alexander; Jaeger, Tim M.; James, Alva R.; Jermann, Philip M.; Kahles, André; Kahraman, Abdullah; Kuebler, Werner; Kunze, Christian P.; Kurzeder, Christian; Levesque, Mitchell; Lombardo, Flavio C.; Lugert, Sebastian; Markolin, Philipp; Mehnert, Martin; Metzler, Julian M.; Muenst, Simone; Murri, Riccardo; Ng, Charlotte K. Y.; Nicolet, Stefan; Lopéz, Monica Nunez; Pedrioli, Patrick GA; Piscuoglio, Salvatore; Prélot, Laurie; Rimmer, Natalie; Ritter, Mathilde; Rommel, Christian; Rosano-González, María L.; Santacroce, Natascha; Schlenker, Ramona; Schwalie, Petra C.; Schwan, Severin; Schär, Tobias; Senti, Gabriela; Shao, Wenguang; Sreedharan, Vipin T.; Stark, Stefan; Stekhoven, Daniel J.; Tanna, Tanmay; Thomas, Tinu M.; Tolnay, Markus; Tosevski, Vinko; Tuncel, Mustafa A.; Van Drogen, Audrey; Vetter, Marcus; Vlajnic, Tatjana; Weber, Sandra; Weber, Walter P.; Wendt, Fabian; Wey, Norbert; Wildschut, Mattheus HE; Ziegler, Johanna; Zimmermann, Marc; Zoche, Martin; Zuend, Gregor; Aebersold, Rudolf; Bacac, Marina; Maass, Gerd; Moch, Holger; Weller, Michael; Theocharides, Alexandre P. A.; Manz, Markus G.; Beerenwinkel, Niko; Beisel, Christian; Pelkmans, Lucas; Snijder, Berend; Wollscheid, Bernd; Heinzelmann, Viola; Bodenmiller, Bernd; Levesque, Mitchell P.; Koelzer, Viktor H.; Rätsch, Gunnar; Dummer, Reinhard; Wicki, Andreas
In the version of the article initially published, the far-right column of the lower panel in Fig. 2c was missing and has now been added, as seen in Fig. 1, below. Additionally, the sentence “L.P. is a founder and shareholder of Apricot Therapeutics - a precision oncology spin-off from the University of Zurich - based on 4i drug response profiling” was missing from the Competing interests statement and has now been added. These corrections have been made to the HTML and PDF versions of the article.
01A - Beitrag in wissenschaftlicher Zeitschrift
Cocreating Awareness and Fostering Action on Violence Resilience. Urban Film-making
(Brill, 09.10.2025) Favre, Céline Anne; Kassis, Wassilis; Aksoy, Dilan
Adolescents experiencing physical abuse by parents range from 20 to 25 percent internationally and in Switzerland, which significantly impacts their socio-emotional development. As part of a Swiss National Science Foundation (SNSF) project, the authors aimed to strengthen the resilient development of youth despite such violence. A participatory, design-based approach was applied to involve adolescents in the development process. In co-creation workshops conducted by the National Coalition Building Institute (NCBI), adolescent participants collaborated with professional video illustrators to create appealing, youth-centered video content. These videos are intended for use on social media and educational platforms to raise awareness about violence resilience, improve access to support services, and facilitate effective learning. By combining current scientific insights from resilience research with creative methods of youth engagement, the project aims to empower adolescents and produces sustainable tools for knowledge transfer. The videos are intended to inform practitioners, shape future research, and create sustainable products for science–practice transfer.
01A - Beitrag in wissenschaftlicher Zeitschrift
Den Sinn bei der Arbeit verstehen und gestalten
(Engeli, 09.2025) Hofer, Doris; Jenny, Gregor J.
Sinn bei der Arbeit ist wichtig - nicht nur für Einzelpersonen, sondern auch für Betriebe, die von engagierten, ans Unternehmen gebundenen Mitarbeitenden profitieren. Dieser Beitrag beleuchtet die Entstehungsmechanismen von Sinn bei der Arbeit und zeigt auf, wie er gezielt gefördert werden kann.
01B - Beitrag in Magazin oder Zeitung