IRF: Institutional Repository FHNW
Willkommen auf der Publikations- und Forschungsdatenbank der Fachhochschule Nordwestschweiz FHNW.
Das IRF ist das digitale Repositorium der FHNW. Es enthält Publikationen, studentische Arbeiten und Projekte.
Weitere Informationen finden Sie im IRF-Handbuch.
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Neuzugänge
Developing an automated preparation of microbiological samples for MALDI-TOF
(Hochschule für Life Sciences FHNW, 2025) Provoost, Jeremy; Hettich, Timm; Gaugler, Stefan; mabritec; CTC Analytics
Bacteria play crucial roles in fields like food, environment, and human health. While some microorganisms are beneficial, such as those in the human gut aiding digestion, others are pathogenic, causing diseases like tuberculosis and Lyme disease [1,2]. Identifying bacteria at the species level is essential for an effective treatment, as susceptibility to antimicrobial agents can vary between species. However, clinical laboratories often rely on broader, less precise identifications, which can lead to a non effective treatment and/or the overuse of broad-spectrum antibiotics, contributing to antibiotic resistance [3]. This could be avoided with a proper sample preparation of the bacteria, which often takes more time. An automated process using a CTC PAL system would be cheap and quick, with the advantage to more precise identification of bacteria species.
11 - Studentische Arbeit
Assessment and pilot lab automation solution for pRED Building 12
(Hochschule für Life Sciences FHNW, 2025) Berger, Cédric; Mosbacher, Johannes; F. Hoffmann-La Roche
Laboratory automation has progressed rapidly over the last decade, driven by high-throughput screening technologies, advanced robotic platforms and the need to provide patients with potentially life changing treatments in a fast and cost effective manner[1]. Although these advancements have improved quality and reproducibility, many R&D settings still rely on a mix of manual, semi-automated and fully automated processes, often using proprietary implementations or various vendor specific software [2]. This thesis evaluates whether current standards, such as Standardization in Lab Automation (SiLA 2) and Laboratory and Analytical Device Standard (LADS), can meet diverse instrumentation needs, streamline device integration, and reduce vendor lock-in. Additionally, the thesis provides strategic recommendations for laboratory automation in the laboratories of Building 12, planned to open in 2029.
11 - Studentische Arbeit
Enhancing patient engagement in hip prosthesis Surgery: A conversational agent using NLP-based question answering and self-reporting tools
(Hochschule für Life Sciences FHNW, 2025) Gogniat, Saengrawi; Martin, Andreas; Swiss Tropical and Public Health
Recent advances in NLP and large language models (LLMs) have enabled conversation agents to deliver human-like conversations. However, in healthcare, challenges such as outdated data, lack of response control, and hallucinations limit their safe use. This project develops a German-language conversational agent to support patients undergoing hip prosthesis surgery by answering questions and collecting health status data (EQ-5D). Using a lightweight Retrieval-Augmented Generation (RAG) approach, the system ensures more accurate, reliable, and context-specific responses while remaining resource-efficient.
11 - Studentische Arbeit
Decentralized wastewater valorization with floating plant systems
(Hochschule für Life Sciences FHNW, 2025) Schweizer, Andreina; Thomann, Michael; Fresh Choice
The Philippines, with its 7,000+ islands, faces severe pressures on coastal ecosystems from climate change, overfishing, and eutrophication1. Untreated wastewater from markets and food industries among others contributes high nitrogen and phosphorus loads, driving algal blooms and oxygen depletion 2. Centralized treatment infrastructure is scarce; most wastewater is discharged untreated or passes only through septic tanks, which remove solids but not nutrients3. Yet, these waste streams also contain valuable resources. Nutrient recovery can reduce environmental impacts while providing substitutes for mineral fertilizers and feed inputs such as soybean meal or fishmeal 4. Floating macrophytes like Azolla and Lemna, with fast growth and high nutrient uptake, offer potential for decentralized wastewater valorization.
11 - Studentische Arbeit
Development of a bioinformatics pipeline for the detection and visualization of mutational signatures in next-generation-sequencing data
(Hochschule für Life Sciences FHNW, 2025) Hodel, Selina; Kahraman, Abdullah; USZ University Hospital Zurich
Cancer is predominantly caused by genetic mutations resulting from exogenous or endogenous processes. Mutational signatures are characteristic patterns of somatic mutations that can indicate the underlying process and thus the etiology of the tumor, such as ultraviolet light, tobacco smoking or defective DNA repair processes and many others. Single base substitutions (SBS) are the most studied mutational signatures. There are 96 SBS categories resulting from the six substitution subtypes: C>A, C>G, C>T, T>A, T>C, and T>G including the immediately neighboring nucleotides (Alexandrov et al., 2020). Detection of mutational signatures in targeted sequencing is much more challenging than in whole genome sequencing data due many times fewer variants present (Lee et al., 2023). Reference signatures can be used to map mutational signatures of tumors.
11 - Studentische Arbeit