Bayer-Oglesby, Lucy
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Bayer-Oglesby, Lucy
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- PublikationValidity of Ambient Levels of Fine Particles as Surrogate for Personal Exposure to Outdoor Air Pollution—Results of the European EXPOLIS-EAS Study (Swiss Center Basel)(Taylor & Francis, 27.12.2011) Bayer-Oglesby, Lucy; Künzli, Nino; Röösli, Martin; Braun-Fahrländer, Charlotte; Mathys, Patrick; Stern, Willem; Jantunen, Matti; Kousa, Anu [in: Journal of the Air & Waste Management Association]To evaluate the validity of fixed-site fine particle levels as exposure surrogates in air pollution epidemiology, we considered four indicator groups: (1) PM2.5 total mass concentrations, (2) sulfur and potassium for regional air pollution, (3) lead and bromine for traffic-related particles, and (4) calcium for crustal particles. Using data from the European EXPOLIS (Air Pollution Exposure Distribution within Adult Urban Populations in Europe) study, we assessed the associations between 48-hr personal exposures and home outdoor levels of the indicators. Furthermore, within-city variability of fine particle levels was evaluated. Personal exposures to PM2.5 mass were not correlated to corresponding home outdoor levels (n = 44, rSpearman (Sp) = 0.07). In the group reporting neither relevant indoor sources nor relevant activities, personal exposures and home outdoor levels of sulfur were highly correlated (n = 40, rSp = 0.85). In contrast, the associations were weaker for traffic (Pb: n = 44, rSp = 0.53; Br: n = 44, rSp = 0.21) and crustal (Ca: n = 44, rSp = 0.12) indicators. This contrast is consistent with spatially homogeneous regional pollution and higher spatial variability of traffic and crustal indicators observed in Basel, Switzerland. We conclude that for regional air pollution, fixed-site fine particle levels are valid exposure surrogates. For source-specific exposures, however, fixed-site data are probably not the optimal measure. Still, in air pollution epidemiology, ambient PM2.5 levels may be more appropriate exposure estimates than total personal PM2.5 exposure, since the latter reflects a mixture of indoor and outdoor sources.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationLiving near main streets and respiratory symptoms in adults. the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults(Oxford University Press, 10.10.2006) Bayer-Oglesby, Lucy; Schindler, Christian; Hazenkamp-von Arx, Marianne E.; Braun-Fahrländer, Charlotte; Keidel, Dirk; Rapp, Regula; Künzli, Nino; Braendli, Otto; Burdet, Luc; Sally Liu, L-J; Leuenberger, Philippe; Ackermann-Liebrich, Ursula [in: American Journal of Epidemiology]The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA), conducted in 1991 (SAPALDIA 1) in eight areas among 9,651 randomly selected adults aged 18-60 years, reported associations among the prevalence of respiratory symptoms, nitrogen dioxide, and particles with an aerodynamic diameter of less than 10 microg/m3. Later, 8,047 subjects reenrolled in 2002 (SAPALDIA 2). The effects of individually assigned traffic exposures on reported respiratory symptoms were estimated, while controlling for socioeconomic and exposure- and health-related factors. The risk of attacks of breathlessness increased for all subjects by 13% (95% confidence interval: 3, 24) per 500-m increment in the length of main street segments within 200 m of the home and decreased in never smokers by 12% (95% confidence interval: 0, 22) per 100-m increment in distance from home to a main street. Living within 20 m of a main street increased the risks of regular phlegm by 15% (95% confidence interval: 0, 31) and wheezing with breathing problems by 34% (95% confidence interval: 0, 79) in never smokers. In 2002, the effects related to road distance were different from those in 1991, which could be due to changes in the traffic pollution mixture. These findings among a general population provide strong confirmation that living near busy streets leads to adverse respiratory health effects.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationPersonal exposure assessment studies may suffer from exposure-relevant selection bias(Nature, 27.07.2000) Bayer-Oglesby, Lucy; Rotko, Tuulia; Krütli, Pius; Boudet, Céline; Kruize, Hanneke; Jantunen, Matti; Künzli, Nino [in: Journal of Exposure Science & Environmental Epidemiology]We evaluated exposure-relevant selection bias within the framework of a study on personal air pollution exposure, using traffic data as exposure proxy. Based on random samples of 3000 (Basel) and 2532 (Helsinki) persons, 50 and 250 subjects, respectively, were recruited for direct monitoring and 250 (Basel, Helsinki) for indirect monitoring. In Basel, participants of direct monitoring as compared to non-participants were more likely to live at streets with low traffic volume (49% below 1st quartile vs. 27%). Adjusted for sex, age and nationality, an increase of 100 cars per hour was associated with 14% less participation (odds ratio (OR): 0.861; 95% CI: 0.731, 1.007). Although in Helsinki, traffic volume was neither significantly related to participation in direct nor indirect monitoring, the point estimates indicate a tendency to decreased participation with increasing traffic intensity at home. We conclude that selection bias regarding exposure-relevant characteristics is likely to occur when recruiting participants for studies including demanding personal exposure assessment. Correction for factors routinely collected may not fully account for exposure-relevant bias. This is of particular importance when using exposure data for modelling population exposure distributions, whereas in epidemiological studies, a reduced range of exposure must not a priori distort the exposure-response relationship.01 - Zeitschriftenartikel, Journalartikel oder Magazin
- PublikationValidity of Annoyance Scores for Estimation of Long Term Air Pollution Exposure in Epidemiologic Studies. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA)(Oxford University Press, 01.07.2000) Bayer-Oglesby, Lucy; Künzli, Nino; Monn, Christian; Schindler, Christian; Ackermann-Liebrich, Ursula; Leuenberger, Philippe [in: American Journal of Epidemiology]In air pollution epidemiology, estimates of long term exposure are often based on measurements made at one fixed site monitor per area. This may lead to exposure misclassification. The present paper validates a questionnaire-based indicator of ambient air pollution levels and its applicability to assess their within-area variability. Within the framework of the SAPALDIA (Swiss Study on Air Pollution and Lung Diseases in Adults) cross-sectional study (1991), 9,651 participants reported their level of annoyance caused by air pollution on an 11-point scale. This subjective measure was compared with annual mean concentrations of particulate matter less than 10 μm in diameter (PM10) and nitrogen dioxide. The impact of individual factors on reported scores was evaluated. Nitrogen dioxide concentrations at home outdoors (measured in 1993), smoking, workplace dust exposure, and respiratory symptoms were found to be predictors of individual annoyance scores. Regression of population mean annoyance scores against annual mean PM10 and nitrogen dioxide concentrations (measured in 1993 and 1991, respectively) across areas showed a linear relation and strong correlations (r > 0.85). Analysis within areas yielded consistent results. The observed associations between subjective and objective air pollution exposure estimates suggest that population mean scores, but not individual scores, may serve as a simple tool for grading air quality within areas. Reported annoyance due to air pollution should be considered an indicator for a complex environmental condition and thus might be used for evaluating the implementation of environmental policies.01A - Beitrag in wissenschaftlicher Zeitschrift