de Wild, Michael
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de Wild, Michael
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- PublikationImmediate stabilization of pedicle screws(De Gruyter, 2023) de Wild, Michael; Zimmermann, Simon; Klein, Karina; Steffen, Thomas; Schlottig, Falko; Hasler, Carol; Rechenberg, Brigitte von [in: Current Directions in Biomedical Engineering]This study was designed as proof of principle and safety test of the novel technique, the Immediate Stabilization System (ISS). The technique is designed to immediately stabilize polymer-augmented pedicle screws (PAS) in deficient bone and avoid complications of loosening pedicle screws at the bone-screw interface, especially in osteoporotic patients. A polymer sleeve was designed as augmentation to improve screw anchorage after drilling the screw hole. By applying ultrasonic energy, the polymeric tube was molded into the pores of the host bone forming a strong and uniform bond with the adjacent bone. The original screw was then implanted into the denser bony environment leading to an enhanced immediate stability. The ISS-treated implants were compared to conventionally placed pedicle screws in ex-vivo cadaver bones (2 sheep spines, n = 6 implants per spine, total 12 screws) and in-vivo in a spinal sheep model (Swiss alpine sheep, n = 5, 4 implants per animal, total 20 screws). The primary stability of ISS-treated pedicle screws was increased in ex-vivo bone (+24% insertion torque (IT)) and in-vivo (+32.9% IT) in sheep spine. Removal torque (RT) was lower in the in PAS tested for 8 weeks in-vivo. The ISS technology demonstrated improved anchorage of pedicle screws in ex-vivo cadaver bones as well as in-vivo studies in sheep spine.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationOsteoconductive Lattice Microarchitecture for Optimized Bone Regeneration(Mary Ann Liebert, 06/2018) de Wild, Michael; Ghayor, Chafik; Zimmermann, Simon; Rüegg, Jasmine; Nicholls, Flora; Schuler, Felix; Chen, Tse-Hsiang; Weber, Franz E. [in: 3D Printing and Additive Manufacturing]Selective laser melting (SLM) is one methodology to realize additive manufacturing and is mainly used to join metal powder in a layer-by-layer manner to produce a solid three-dimensional (3D) object. For bone tissue engineering purposes, scaffolds can readily be designed as 3D data model and realized with titanium known for its excellent osseointegration behavior. The microarchitecture, that is, design with submillimeter features, of additively manufactured scaffolds is in many cases a lattice structure. This study aimed to apply SLM that allows a high degree of microarchitectural freedom to generate lattice structures and to determine the optimal distance between rods and the optimal diameter of rods for osteoconduction (bone ingrowth into scaffolds) and bone regeneration. For the biological readout, diverse SLM-fabricated titanium implants were placed in the calvarium of rabbits and new bone formation and defect bridging were determined after 4 weeks of healing. The results from the middle section of the defects show that with a lattice microarchitecture, the optimal distance between titanium rods is around 0.8 mm and the optimal rod dimension is between 0.3 and 0.4 mm to optimize defect bridging and bone regeneration.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationReduction of particles on SLM surfaces(2018) Zimmermann, Simon; Schumacher, Ralf; Bill, Oliver; Dalcanale, Federico; de Wild, Michael [in: Meet the Expert Conference]04 - Beitrag Sammelband oder Konferenzschrift
- PublikationMarker for the pre-clinical development of bone substitute materials(De Gruyter, 2017) de Wild, Michael; Zimmermann, Simon; Obrecht, Marcel; Dard, Michel [in: Current Directions in Biomedical Engineering]Thin mechanically stable Ti-cages have been developed for the in-vivo application as X-ray and histology markers for the optimized evaluation of pre-clinical performance of bone graft materials. A metallic frame defines the region of interest during histological investigations and supports the identification of the defect site. This standardization of the procedure enhances the quality of pre-clinical experiments. Different models of thin metallic frameworks were designed and produced out of titanium by additive manufacturing (Selective Laser Melting). The productibility, the mechanical stability, the handling and suitability of several frame geometries were tested during surgery in artificial and in ex-vivo bone before a series of cages was preclinically investigated in the female Göttingen minipigs model. With our novel approach, a flexible process was established that can be adapted to the requirements of any specific animal model and bone graft testing.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationInfluence of microarchitecture on osteoconduction and mechanics of porous titanium scaffolds generated by selective laser melting(Mary Ann Liebert, 2016) de Wild, Michael; Zimmermann, Simon; Rüegg, Jasmine; Schumacher, Ralf; Fleischmann, Thea; Ghayor, Chafik; Weber, Franz E. [in: 3D Printing and Additive Manufacturing]Bone regeneration is naturally based on bone forming cells, osteoinduction by diverse growth factors, and osteoconduction. The latter one used as term in this study is the ingrowth of bone in 3D structures, which leads to an optimal case in creeping substitution of the scaffold by newly formed bone. Autologous bone is still the gold standard for bone substitutes. In most cases, newly developed bone substitutes consist of calcium phosphate, since hydroxyapatite is the main component of bone and mimics cancellous bone in microstructure. In this study, we wanted to elucidate the optimal microarchitecture for osteoconduction and determine compression strength and Young’s Modulus of the selected architectures. Selective laser melting of titanium was used as tool to generate diverse architectures in a repetitive and precise way. To link 3D scaffold architecture to biological readouts, bone ingrowth, bone to implant contact, and defect bridging of noncritical-sized defects in the calvarial bone of rabbits were determined. In this series, 5 different microarchitectures were tested with pore sizes ranging from 700 to 1300 lm and constrictions between 290 and 700 lm. To our surprise, all microstructures showed the same biological response of excellent osteoconduction. However, the mechanical yield strength of these structures differed by the factor of three and reached up to three times the strength of cancellous bone at a porosity of 72.3–88.4%. These results suggest that the microarchitecture of bone substitutes can be optimized toward mechanical strength in a wide range of constrictions and pore sizes without having a negative influence on osteoconduction.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationNew Lasso-Loop 360° Technique For Arthroscopic Suprapectoral Biceps Tenodesis – A Biomechanical Comparison(2016) de Wild, Michael; Rosso, Claudio; Müller, Sebastian; Flury, Rebekka; Zimmermann, Simon; Lafosse, Laurent; Bongiorno, Vito06 - Präsentation
- PublikationImprovement of mechanical properties of 3D printed hydroxyapatite scaffolds by culture of osteoblast-like cells under perfusion flow(2015) Hugot Beaufils, Marina; Chavanne, Philippe; Rimmer, Natalie; Burgio, Floriana; Rohner, Adrian; Schumacher, Ralf; de Wild, Michael; Martin, Yvan; Pieles, Uwe; Zimmermann, Simon; Papadimitropoulos, Adam [in: European Cells and Materials]04 - Beitrag Sammelband oder Konferenzschrift
- PublikationStiffness - anisotropy of porous implant geometries(2015) de Wild, Michael; Schumacher, Ralf; Rüegg, Jasmine; Zimmermann, Simon; Weber, Franz E. [in: eCM Congress XVI]04 - Beitrag Sammelband oder Konferenzschrift
- PublikationAll-inside meniscal repair devices compared with their matched inside-out Vertical mattress suture repair. Introducing 10,000 and 100,000 loading cycles(SAGE, 01.09.2014) Rosso, Claudio; Müller, Sebastian; Buckland, Daniel M.; Schwenk, Tanja; Zimmermann, Simon; de Wild, Michael; Valderrabano, Victor [in: The American Journal of Sports Medicine]All-inside arthroscopic meniscal repairs are favored by most clinicians because of their lower complication rate and decreased morbidity compared with inside-out techniques. Until now, only 1000 cycles have been used for biomechanical testing. Hypothesis: All-inside meniscal repairs will show inferior biomechanical response to cyclic loading (up to 100,000 cycles) and load-to-failure testing compared with inside-out suture controls. Study Design: Controlled laboratory study. Methods: Bucket-handle tears in 72 porcine menisci were repaired using the Omnispan and Fast-Fix 360 (all-inside devices) and Orthocord 2-0 and Ultrabraid 2-0 sutures (matched controls). Initial displacement, displacement after cyclic loading (100, 500, 1000, 2000, 5000, 10,000, and 100,000 cycles) between 5 and 20 N, ultimate load to failure, and mode of failure were recorded, as well as stiffness. Results: Initial displacement and displacement after cyclic loading were not different between the groups. The Omnispan repair demonstrated the highest load-to-failure force (mean 6 SD, 151.3 6 21.5 N) and was significantly stronger than all the other constructs (Orthocord 2-0, 105.5 6 20.4 N; Ultrabraid 2-0, 93.4 6 22.5 N; Fast-Fix 360, 76.6 6 14.2 N) (P \ .0001 for all). The Orthocord vertical inside-out mattress repair was significantly stronger than the Fast-Fix 360 repair (P = .003). The Omnispan (30.8 6 3.5 N/mm) showed significantly higher stiffness compared with the Ultrabraid 2-0 (22.9 6 6.9 N/mm, P \ .0001) and Fast-Fix 360 (23.7 6 3.9 N/mm, P = .001). The predominant mode of failure was suture failure. Conclusion: All-inside meniscal devices show comparable biomechanical properties compared with inside-out suture repair in cyclic loading, even after 100,000 cycles. Clinical Relevance: Eight to 10 weeks of rehabilitation might not pose a problem for all repairs in this worst-case scenario.01A - Beitrag in wissenschaftlicher Zeitschrift