Hemm-Ode, Simone
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Hemm-Ode
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Simone
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Hemm-Ode, Simone
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- PublikationAtlas Optimization for Deep Brain Stimulation(IFMBE, 30.11.2020) Vogel, Dorian; Wardell, Karin; Coste, Jérôme; Lemaire, Jean-Jaques; Hemm-Ode, Simone; Jarm, Tomaz; Cvetkoska, Aleksandra; Mahnič-Kalamiza, Samo; Miklavcic, Damijan [in: EMBEC 2020: 8th European Medical and Biological Engineering]Abstract : Electrical stimulation of the deep parts of the brain is the standard answer for patients subject to drug-refractory movement disorders. Collective analysis of data collected during surgeries are crucial in order to provide more systematic planning assistance and understanding the physiological mechanisms of action. To that end, the process of normalizing anatomies captured with Magnetic Resonance imaging across patients is a key component. In this work, we present the optimization of a workflow designed to create group-specific anatomical templates: a group template is refined iteratively using the results of successive non-linear image registrations with refinement steps in the in the basal-ganglia area. All non-linear registrations were executed using the Advanced Normalization Tools (ANTs) and the quality of the nor-malization was measured using spacial overlap of anatomical structures manually delineated during the planning of the surgery. The parameters of the workflow evaluated were: the use of multiple modalities sequentially or together during each registration to the template, the number of iterations in the template creation and the fine settings of the non-linear registration tool. Using the T1 and white matter attenuated inverse recovery modalities (WAIR) together produced the best results, especially in the center of the brain. The optimal numbers of iterations of the template creation were higher than those from the literature and our previous works. Finally, the setting of the non-linear registration tool that improved results the most was the activation of the registration with the native voxel sizes of images, as opposed to down-sampled version of the images. The normalization process was optimized over our previous study and allowed to obtain the best possible anatomical nor-malization of this specific group of patient. It will be used to summarize and analyze peri-operative measurements during test stimulation. The aim is that the conclusions obtained from this analysis will be useful for assistance during the planning of new surgeries.04B - Beitrag Konferenzschrift
- PublikationA novel assistive method for rigidity evaluation during deep brain stimulation surgery using acceleration sensors(American Association of Neurological Surgeons, 09/2017) Shah, Ashesh; Coste, Jérôme; Lemaire, Jean-Jaques; Schkommodau, Erik; Taub, Ethan; Guzman, Raphael; Hemm-Ode, Simone [in: Journal of Neurosurgery]01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationPatient-specific electric field simulations and acceleration measurements for objective analysis of intraoperative stimulation tests in the thalamus(Frontiers, 25.11.2016) Hemm-Ode, Simone; Pison, Daniela; Alonso, Fabiola; Shah, Ashesh; Coste, Jérôme; Lemaire, Jean-Jaques; Wårdell, Karin [in: Frontiers in Human Neuroscience]01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationImproving DBS targeting using 3D visualization of intraoperative stimulation tests(09/2016) Shah, Ashesh; Alonso, Fabiola; Lemaire, Jean-Jaques; Wardell, Karin; Pison, Daniela; Coste, Jérôme; Schkommodau, Erik; Hemm-Ode, Simone06 - Präsentation
- PublikationIntraoperative quantitative tremor evaluation in deep brain stimulation surgery(09/2016) Shah, Ashesh; Coste, Jérôme; Lemaire, Jean-Jaques; Taub, Ethan; Schüpbach, W.M. Michael; Pollo, Claudio; Guzman, Raphael; Wardell, Karin; Schkommodau, Erik; Hemm-Ode, Simone06 - Präsentation
- PublikationImprovement maps: A Technique to visualise intraoperative stimulation test data(08/2016) Shah, Ashesh; Alonso, Fabiola; Lemaire, Jean-Jaques; Pison, Daniela; Wardell, Karin; Coste, Jérôme; Schkommodau, Erik; Hemm-Ode, Simone06 - Präsentation
- Publikation3D Visualization of intraoperative stimulation test results for better target selection in DBS surgery (U-PP-04)(2016) Shah, Ashesh; Alonso, Fabiola; Pison, Daniela; Lemaire, Jean-Jaques; Wårdell, Karin; Coste, Jérôme; Schkommodau, Erik; Hemm-Ode, Simone06 - Präsentation
- PublikationIntraoperative acceleration measurements to quantify tremor during deep brain stimulation surgery(Springer, 2016) Shah, Ashesh; Coste, Jérôme; Lemaire, Jean-Jaques; Taub, Ethan; Schüpbach, W.M. Michael; Pollo, Claudio; Schkommodau, Erik; Guzman, Raphael; Hemm-Ode, Simone [in: Medical & Biological Engineering & Computing]Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a new, versatile method for quantitative intraoperative evaluation of improvement in tremor with an acceleration sensor that is mounted on the patient’s wrist during surgery. At each anatomical test position, the improvement in tremor compared to the initial tremor is estimated on the basis of extracted outcome measures. This method was tested on 15 tremor patients undergoing DBS surgery in two centers. Data from 359 stimulation tests were acquired. Our results suggest that accelerometric evaluation detects tremor changes more sensitively than subjective visual ratings. The effective stimulation current amplitudes identified from the quantitative data (1.1 ± 0.8 mA) are lower than those identified by visual evaluation (1.7 ± 0.8 mA) for similar improvement in tremor. Additionally, if these data had been used to choose the chronic implant position of the DBS lead, 15 of the 26 choices would have been different. These results show that our method of accelerometric evaluation can potentially improve DBS targeting.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA method for side effect analysis based on electric field simulations for intraoperative test stimulation in deep brain stimulation surger y(2015) Pison, Daniela; Alonso, Fabiola; Wårdell, Karin; Shah, Ashesh; Coste, Jérôme; Lemaire, Jean-Jaques; Schkommodau, Erik; Hemm-Ode, Simone [in: World Congress on Medical Physics and Biomedical Engineering (IUPESM)]04 - Beitrag Sammelband oder Konferenzschrift