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Auflistung nach Autor/Autorin "Hamburger, Matthias"

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      Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone 

      Jähne, Evelyn A.; Eigenmann, Daniela E.; Moradi-Afrapoli, Fahimeh; Verjee, Sheela; Butterweck, Veronika; Hebeisen, Simon; Hettich, Timm; Schlotterbeck, Götz; Smiesko, Martin; Hamburger, Matthias; Oufir, Mouhssin (2016)
      Planta Medica
      Tryptanthrin and (E,​Z)​-​3-​(4-​hydroxy-​3,​5-​dimethoxybenzylidene)​indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-​inflammatory and antiallergic alkaloids, and shown to inhibit COX-​2, ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      Development and full validation of an UPLC-MS/MS method for the quantification of the plant-derived alkaloid indirubin in rat plasma 

      Jähne, Evelyn A.; Butterweck, Veronika; Hamburger, Matthias; Oufir, Mouhssin; Sampath, Chethan (2016)
      Journal of Pharmaceutical and Biomedical Analysis
      An UPLC-MS/MS method for the quantification of indirubin in lithium heparinized rat plasma was developed and validated according to current international guidelines. Indirubin was extracted from rat plasma by using Waters ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding 

      Zabela, Volha; Hettich, Timm; Schlotterbeck, Götz; Wimmer, Laurin; Mihovilovic D., Marko; Guillet, Fabrice; Belkacem, Bouaita; Shevchenko, Bénédicte; Hamburger, Matthias; Oufir, Mouhssin (2017-12)
      Journal of Chromatography B
      In a screening of natural products for allosteric modulators of GABAA receptors (γ-aminobutyric acid type A receptor), piperine was identified as a compound targeting a benzodiazepine-independent binding site. Given that ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract 

      Corradi, Elisabetta; Schmidt, Nadine; Räber, Nathalie; De Mieri, Maria; Hamburger, Matthias; Potterat, Oliver; Butterweck, Veronika (2017)
      Planta Medica
      Phenolic constituents of Salix reticulata (Salicaceae) and antiproliferative activity of an extract and individual compounds were investigated in immortalized human non-tumorigenic keratinocytes (HaCaT). A MeOH extract ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      Pharmacokinetics and in vitro blood-brain barrier screening of the plant-derived alkaloid tryptanthrin 

      Jähne, Evelyn A.; Eigenmann, Daniela E.; Sampath, Chethan; Butterweck, Veronika; Culot, Maxime; Cecchelli, Roméo; Gosselet, Fabien; Walter, Fruzsina R.; Deli, Maria A.; Smiesko, Martin; Hamburger, Matthias; Oufir, Mouhssin (2016)
      Planta Medica
      The indolo[2,1-b]quinazoline alkaloid tryptanthrin was previously identified as a potent anti-inflammatory compound with a unique pharmacological profile. It is a potent inhibitor of cyclooxygenase-2, 5-lipooxygenase-catalyzed ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      Pharmacokinetics of dietary kaempferol and its metabolite 4-hydroxyphenylacetic acid in rats 

      Zabela, Volha; Sampath, Chethan; Oufir, Mouhssin; Moradi-Afrapoli, Fahimeh; Butterweck, Veronika; Hamburger, Matthias (2016-12)
      Fitoterapia
      SCOPE: Kaempferol is a major flavonoid in the human diet and in medicinal plants. The compound exerts anxiolytic activity when administered orally in mice, while no behavioural changes were observed upon intraperitoneal ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      Saffron Flower Extract Promotes Scratch Wound Closure of Keratinocytes and Enhances VEGF Production 

      Verjee, Sheela; Garo, Eliane; Pelaez, Sarah; Fertig, Orlando; Hamburger, Matthias; Butterweck, Veronika (2017)
      Planta Medica
      During saffron (Crocus sativus) spice production, large amounts of floral biowaste are generated. It was the aim of this study to develop a value-added product from saffron floral biowaste to be used as a natural cosmetic ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      Saponins from saffron corms inhibit the gene expression and secretion of pro-inflammatory cytokines 

      Keller, Morris; Fankhauser, Sarah; Giezendanner, Noreen; König, Michelle; Keresztes, Franziska; Danton, Ombeline; Fertig, Orlando; Marcourt, Laurence; Butterweck, Veronika; Potterat, Olivier; Hamburger, Matthias (2021-02-18)
      Natural Products
      Corms are obtained as a byproduct during the cultivation of saffron (Crocus sativus). In a project aimed at the valorization of this waste product, we observed that a 70% EtOH extract of the corms and a sugar-depleted MeOH ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
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      Validation of UHPLC–MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies 

      Moradi-Afrapoli, Fahimeh; Oufir, Mouhssin; Walter, Fruzsina R.; Deli, Maria A.; Smiesko, Martin; Zabela, Volha; Butterweck, Veronika; Hamburger, Matthias (2016-09-05)
      Journal of Pharmaceutical and Biomedical Analysis
      01A - Beitrag in wissenschaftlicher Zeitschrift

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