Auflistung nach Autor/Autorin "Schönenberger, Monica"
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Early stages of drug crystallization from amorphous solid dispersion via fractal analysis based on chemical imaging
(2018-12)European Journal of Pharmaceutics and BiopharmaceuticsEarly stages of crystallization from amorphous solid dispersion (ASD) are typically not detected by means of standard methods like powder X-ray diffraction (XRPD). The aim of this study is therefore to evaluate if fractal ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Flow-through cross-polarized imaging as a new tool to overcome the analytical sensitivity challenges of a low-dose crystalline compound in a lipid matrix
(2015-11-10)Journal of Pharmaceutical and Biomedical AnalysisAssessing the physical state of a low-dose active compound in a solid lipid or polymer matrix is analytically challenging, especially if the matrix exhibits some crystallinity. The aim of this study was first to compare ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer
(2019)Molecular PharmaceuticsHot melt extrusion (HME) has become an essential technology to cope with an increasing number of poorly soluble drug candidates. However, there is only a limited choice of pharmaceutical polymers for obtaining suitable ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Molecularly designed lipid microdomains for solid dispersions using a polymer/inorganic carrier matrix produced by hot-melt extrusion
(2016-02-29)International Journal of PharmaceuticsAmorphous solid dispersions have for many years been a focus in oral formulations, especially in combination with a hot-melt extrusion process. The present work targets a novel approach with a system based on a fatty acid, ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Temperature-Induced Surface Effects on Drug Nanosuspensions
(2018-02)Pharmaceutical ResearchPurpose The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are ...01 - Zeitschriftenartikel, Journalartikel oder Magazin
