Auflistung nach Autor/Autorin "Ditzinger, Felix"
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Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
(2018-07)Journal of Pharmacy and PharmacologyObjectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review
(2018-05)Journal of Pharmacy and PharmacologyObjectives Supersaturating formulations hold great promise for delivery of poorly soluble active pharmaceutical ingredients (APIs). To profit from supersaturating formulations, precipitation is hindered with precipitation ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
In Vivo Performance of Innovative Polyelectrolyte Matrices for Hot Melt Extrusion of Amorphous Drug Systems
(2020)Molecular PharmaceuticsHot melt extrusion of amorphous systems has become a pivotal technology to cope with challenges of poorly water-soluble drugs. Previous research showed that small molecular additives with targeted molecular interactions ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches | a PEARRL review
(2019-04)Journal of Pharmacy and Pharmacology01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review
(2018-08)Journal of Pharmacy and PharmacologyObjectives This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
(2020-01-30)International Journal of Pharmaceutics01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Modified Polymer Matrix in Pharmaceutical Hot Melt Extrusion by Molecular Interactions with a Carboxylic Coformer
(2019)Molecular PharmaceuticsHot melt extrusion (HME) has become an essential technology to cope with an increasing number of poorly soluble drug candidates. However, there is only a limited choice of pharmaceutical polymers for obtaining suitable ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies
(2019-11-04)PharmaceuticsAmorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Polyelectrolytes in Hot Melt Extrusion: A Combined Solvent-Based and Interacting Additive Technique for Solid Dispersions
(2019)PharmaceuticsSolid dispersions are important supersaturating formulations to orally deliver poorly water-soluble drugs. A most important process technique is hot melt extrusion but process requirements limit the choice of suitable ...01 - Zeitschriftenartikel, Journalartikel oder Magazin
