Auflistung nach Autor/Autorin "Hettich, Timm"
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Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells
Alam, Shahidul; Anugraham, Merrina; Huang, Yen-Lin; Kohler, Reto; Hettich, Timm; Winkelbach, Katharina; Grether, Yasmin; Nunez Lopez, Monica; Khasbiullina, Nailia; Bovin, Nicolai V.; Schlotterbeck, Götz; Jacob, Francis (2017-03-30)Scientific ReportsThe (neo-) lacto series glycosphingolipids (nsGSLs) comprise of glycan epitopes that are present as blood group antigens, act as primary receptors for human pathogens and are also increasingly associated with malignant ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio)
Faltermann, Susanne; Hutter, Simon; Christen, Verena; Hettich, Timm; Fent, Karl (2016-07-14)ToxinsIntensive growth of cyanobacteria in freshwater promoted by eutrophication can lead to release of toxic secondary metabolites that may harm aquatic organisms and humans. The serine protease inhibitor aeruginosin 828A was ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Biodegradation of sulfamethoxazole by a bacterial consortium of Achromobacter denitrificans PR1 and Leucobacter sp. GP
Reis, Ana C.; Cvancarova Småstuen, M.; Liu, Ying; Lenz, Markus; Hettich, Timm; Kolvenbach, Boris; Corvini, Philippe; Nunes, Olga C. (2018-12)Applied Microbiology and BiotechnologyIn the last decade, biological degradation and mineralization of antibiotics have been increasingly reported feats of environmental bacteria. The most extensively described example is that of sulfonamides that can be ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone
Jähne, Evelyn A.; Eigenmann, Daniela E.; Moradi-Afrapoli, Fahimeh; Verjee, Sheela; Butterweck, Veronika; Hebeisen, Simon; Hettich, Timm; Schlotterbeck, Götz; Smiesko, Martin; Hamburger, Matthias; Oufir, Mouhssin (2016)Planta MedicaTryptanthrin and (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-inflammatory and antiallergic alkaloids, and shown to inhibit COX-2, ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos
Willi, Raffael Alois; Faltermann, Susanne; Hettich, Timm; Fent, Karl (2019-07-01)Science of the Total EnvironmentMany glucocorticoids occur in the aquatic environments but their adverse effects to fish are poorly known. Here we investigate effects of the natural glucocorticoid corticosterone and the synthetic glucocorticoids betamethasone ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients
Kohler, Reto; Anugraham, Merrina; Nunez Lopez, Monica; Xiao, Christina; Schoetzau, Andreas; Hettich, Timm; Schlotterbeck, Götz; Fedier, André; Jacob, Francis; Heinzelmann-Schwarz, Viola (2016-07-12)OncotargetBisecting GlcNAc on N-glycoproteins is described in E-cadherin-, EGF-, Wnt- and integrin- cancer-associated signaling pathways. However, the mechanisms regulating bisecting GlcNAc expression are not clear. Bisecting ...01A - Beitrag in wissenschaftlicher Zeitschrift -
GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding
Zabela, Volha; Hettich, Timm; Schlotterbeck, Götz; Wimmer, Laurin; Mihovilovic D., Marko; Guillet, Fabrice; Belkacem, Bouaita; Shevchenko, Bénédicte; Hamburger, Matthias; Oufir, Mouhssin (2017-12)Journal of Chromatography BIn a screening of natural products for allosteric modulators of GABAA receptors (γ-aminobutyric acid type A receptor), piperine was identified as a compound targeting a benzodiazepine-independent binding site. Given that ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Metabolic Profiling
Berchtold, Christian; Hettich, Timm; Schlotterbeck, Götz; Senner, Frank (2015)GIT: Labor-Fachzeitschrift01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Novel Analytical Workflow for Comprehensive
Hettich, Timm; Schlotterbeck, Götz (2015)Chimia01A - Beitrag in wissenschaftlicher Zeitschrift -
Tradeoff between micropollutant abatement and bromate formation during ozonation of concentrates from nanofiltration and reverse osmosis processes
Wünsch, Robin; Hettich, Timm; Prahtel, Marlies; Thomann, Michael; Wintgens, Thomas; Von Gunten, Urs (2022)Water ResearchWater treatment with nanofiltration (NF) or reverse osmosis (RO) membranes results in a purified permeate and a retentate, where solutes are concentrated and have to be properly managed and discharged. To date, little is ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Validation of a commercial enzyme-linked immunosorbent assay for allopregnanolone in the saliva of healthy pregnant women
Grötsch, Maria Katharina; Wietor, Denise Margret; Hettich, Timm; Ehlert, Ulrike (2022-09-27)BiomoleculesEnzyme-linked immunosorbent assays (ELISAs) for saliva are simple, non-invasive methods for hormone detection. Allopregnanolone (ALLO) is a neuroactive steroid hormone that plays a crucial role in the aetiology of reproductive ...01A - Beitrag in wissenschaftlicher Zeitschrift -
A Versatile Biocompatible Antibiotic Delivery System Based on Self‐Assembling Peptides with Antimicrobial and Regenerative Potential
Koch, Franziska; Kilian, David; Hettich, Timm; Germershaus, Oliver (2019-04-15)Advanced Healthcare MaterialsPeriodontitis is a chronic inflammatory and tissue‐destructive disease. Since the polymicrobiome in the oral cavity makes it difficult to treat, novel therapeutic strategies are required. Hydrogels based on self‐assembling ...01A - Beitrag in wissenschaftlicher Zeitschrift -
A vitellogenin antibody in honey bees (Apis mellifera ): Characterization and application as potential biomarker for insecticide exposure
Christen, Verena; Fent, Karl; Hettich, Timm (2019-02)Environmental Toxicology and ChemistryThe insect yolk precursor vitellogenin is a lipoglycoprotein synthesized and stored in the fat body and secreted into the hemolymph. In honey bees, vitellogenin displays crucial functions in hormone signaling, behavioral ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study
Cuenod, Aline; Wüthrich, Daniel; Seth-Smith, Helena; Ott, Chantal; Gehringer, Christian; Foucaul, Frederic; Mouchet, Roxanne; Kassim, Ali; Revathi, Gunturu; Vogt, Deborah; von Felten, Stefanie; Bassetti, Stefano; Tschudin-Sutter, Sarah; Hettich, Timm; Schlotterbeck, Götz; Homberger, Christina; Casanova, Carlo; Moran-Gilad, Jakob; Sagi, Orli; Rodriguez-Sanchez, Belen; Müller, Franco; Aerni, Martina; Gaia, Valeria; van Dessel, Helke; Kampinga, Greetje; Müller, Claudia; Daubenberger, Claudia; Pflüger, Valentin; Egli, Adrian (2021)Genome MedicineBackground Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently ...01A - Beitrag in wissenschaftlicher Zeitschrift