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Publikation 3D human liver microtissues vs. 2D monolayer culture as an in vitro tool for compound testing(10/2018) Messner, Catherine; Prestigiacomo, Vincenzo; Mannino, Salvatore; Mauch, Linda; Suter-Dick, Laura06 - PräsentationPublikation 3D manufacturing of metallic implants(05/2016) de Wild, MichaelThe design, manufacturing and testing of load-bearing implants made of titanium, titanium alloy and magnesium produced by selective laser melting (SLM) will be presented. Analytical, structural, mechanical, in-silico, in-vitro and in-vivo studies are indispensable to verify the performance of such novel biomaterials. In particular the results from 3D-printed shape memory implants will be discussed.06 - PräsentationPublikation 3D printed microfluidic modules. Passive mixers and cells encapsulation in alginate(De Gruyter, 02.09.2022) Dalcanale, Federico; Caj, Michaela; Schuler, Felix; Ganeshanathan, Kireedan; Suter-Dick, LauraPassive mixers and droplet generation microfluidic chip modules were designed and manufactured using a commercial SLA 3D-printer. The mixing modules were designed specifically for 3D-printing and evaluated using FEM modeling. The co-flow droplet generator was used for cancer cells encapsulation and drug potency evaluation.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation 3D Printing and Medical Applications - an Overview(2016) Schumacher, Ralf06 - PräsentationPublikation 3D Printing in Medicine: Revolution or Illusion?(2016) Schumacher, Ralf06 - PräsentationPublikation 3D Printing in Medicine: Revolution or Illusion?(2016) Schumacher, Ralf06 - PräsentationPublikation 3D Printing in Medicine: Yesterday – Today - Tomorrow(06/2016) Schumacher, Ralf06 - PräsentationPublikation 06 - PräsentationPublikation 3D Visualization of intraoperative stimulation test results for better target selection in DBS surgery (U-PP-04)(2016) Shah, Ashesh; Alonso, Fabiola; Pison, Daniela; Lemaire, Jean-Jaques; Wårdell, Karin; Coste, Jérôme; Schkommodau, Erik; Hemm-Ode, Simone06 - PräsentationPublikation 3D-Druck in der Medizintechnik – Revolution, Evolution oder Illusion?(2016) Schumacher, Ralf06 - PräsentationPublikation 3D-Druck und neue Geschäftsmodelle in der Medizintechnik(2015) Schumacher, Ralf06 - PräsentationPublikation 3D-Druck wird Chirurgen die Operationen erleichtern(Swiss Professional Media, 04/2015) Schumacher, Ralf01B - Beitrag in Magazin oder ZeitungPublikation 3D-printed auxetic structures for bio-medical application(2018) Schuler, Felix; Renaud, Pascal; de Wild, Michael04B - Beitrag KonferenzschriftPublikation 3D-printed LEGO®-inspired titanium scaffolds for patient-specific regenerative medicine(Elsevier, 2023) Lee, Seunghun S.; Du, Xiaoyu; Smit, Thijs; Bissacco, Elisa G.; Seiler, Daniel; de Wild, Michael; Ferguson, Stephen J.Despite the recent advances in 3D-printing, it is often difficult to fabricate implants that optimally fit a defect size or shape. There are some approaches to resolve this issue, such as patient-specific implant/scaffold designs based on CT images of the patients, however, this process is labor-intensive and costly. Especially in developing countries, affordable treatment options are required, while still not excluding these patient groups from potential material and manufacturing advances. Here, a selective laser melting (SLM) 3D-printing strategy was used to fabricate a hierarchical, LEGO®-inspired Assemblable Titanium Scaffold (ATS) system, which can be manually assembled in any shape or size with ease. A surgeon can quickly create a scaffold that would fit to the defect right before the implantation during the surgery. Additionally, the direct inclusion of micro- and macroporous structures via 3D-printing, as well as a double acid-etched surface treatment (ST) in the ATS, ensure biocompatibility, sufficient nutrient flow, cell migration and enhanced osteogenesis. Three different structures were designed (non-porous:NP, semi-porous:SP, ultra-porous:UP), 3D-printed with the SLM technique and then surface treated for the ST groups. After analyzing characteristics of the ATS such as printing quality, surface roughness and interconnected porosity, mechanical testing and finite element analysis (FEA) demonstrated that individual and stacked ATS have sufficient mechanical properties to withstand loading in a physiological system. All ATS showed high cell viability, and the SP and UP groups demonstrated enhanced cell proliferation rates compared to the NP group. Furthermore, we also verified that cells were well-attached and spread on the porous structures and successful cell migration between the ATS units was seen in the case of assemblies. The UP and SP groups exhibited higher calcium deposition and RT-qPCR proved higher osteogenic gene expression compared to NP group. Finally, we demonstrate a number of possible medical applications that reveal the potential of the ATS through assembly. © 2023 The Authors01A - Beitrag in wissenschaftlicher ZeitschriftPublikation A baseline wander tracking system for artifact rejection in long-term electrocardiography(IEEE, 2016) Niederhauser, Thomas; Marisa, Thanks; Kohler, Lukas; Haeberlin, Andreas; Wildhaber, Reto; Abächerli, Roger; Goette, Josef; Jacomet, Marcel; Vogel, RolfLong-term electrocardiogram (ECG) signals might suffer from relevant baseline disturbances during physical activity. Motion artifacts in particular are more pronounced with dry surface or esophageal electrodes which are dedicated to prolonged ECG recording. In this paper we present a method called baseline wander tracking (BWT) that tracks and rejects strong baseline disturbances and avoids concurrent saturation of the analog front-end. The proposed algorithm shifts the baseline level of the ECG signal to the middle of the dynamic input range. Due to the fast offset shifts, that produce much steeper signal portions than the normal ECG waves, the true ECG signal can be reconstructed offline and filtered using computationally intensive algorithms. Based on Monte Carlo simulations we observed reconstruction errors mainly caused by the non-linearity inaccuracies of the DAC. However, the signal to error ratio of the BWT is higher compared to an analog front-end featuring a dynamic input ranges above 15 mV if a synthetic ECG signal was used. The BWT is additionally able to suppress (electrode) offset potentials without introducing long transients. Due to its structural simplicity, memory efficiency and the DC coupling capability, the BWT is dedicated to high integration required in long-term and low-power ECG recording systems.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation A Biocatalytic Nanomaterial for the Label-Free Detection of Virus-Like Particles(Wiley, 2017) Sykora, Sabine; Correro, Maria Rita; Moridi, Negar; Belliot, Gaël; Pothier, Pierre; Dudal, Yves; Corvini, Philippe; Shahgaldian, PatrickThe design of nanomaterials that are capable of specific and sensitive biomolecular recognition is an on-going challenge in the chemical and biochemical sciences. A number of sophisticated artificial systems have been designed to specifically recognize a variety of targets. However, methods based on natural biomolecular detection systems using antibodies are often superior. Besides greater affinity and selectivity, antibodies can be easily coupled to enzymatic systems that act as signal amplifiers, thus permitting impressively low detection limits. The possibility to translate this concept to artificial recognition systems remains limited due to design incompatibilities. Here we describe the synthesis of a synthetic nanomaterial capable of specific biomolecular detection by using an internal biocatalytic colorimetric detection and amplification system. The design of this nanomaterial relies on the ability to accurately grow hybrid protein-organosilica layers at the surface of silica nanoparticles. The method allows for label-free detection and quantification of targets at picomolar concentrations.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation A cyclodextrin-based polymer (CDP) for sensing diclofenac in water(Elsevier, 15.12.2015) Xiao, Pu; Weibel, Nicolas; Dudal, Yves; Corvini, Philippe; Shahgaldian, Patrick01A - Beitrag in wissenschaftlicher Zeitschrift