Hradetzky, David

Hradetzky

David

Hradetzky, David

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Interferometric sensor platform for biomolecular interaction analysis
(VDE, 2005) Hradetzky, David; Müller, Claas; Reinecke, Holger [in: Mikrosystemtechnik-Kongress 2005]
04B - Beitrag Konferenzschrift
Label free detection of biomolecular interactions
(IEEE, 2005) Hradetzky, David; Müller, Claas; Reinecke, Holger [in: IEEE/LEOS International Conference on Optical MEMS and Their Applications Conference, 2005.]
This work presents a simple evanescent wave sensing system based on an interferometric approach suitable to meet the demands on label free sensor systems for the detection of biomolecular interactions especially. It is representing a basic concept towards high throughput application. The system performance and reproducibility was evaluated with refractometric measurements of sucrose dilutions. A mean resolution of the effective refractive index of 3sigma(Deltamacrnmacr eff )=0.9middot10 -6 without averaging and a reproducibility below sigma r =0.1middot10 -6 were achieved. The suitability for the detection of biomolecular interactions was validated with the detection of a DNA hybridization
04B - Beitrag Konferenzschrift