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Supersaturated Lipid-Based Formulations to Enhance the Oral Bioavailability of Venetoclax
(2020-06-18)
Pharmaceutics
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review
(2018-06)
Journal of Pharmacy and Pharmacology
Objectives
Drug precipitation in vivo poses a significant challenge for the pharmaceutical industry. During the drug development process, the impact of drug supersaturation or precipitation on the in vivo behaviour of ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Trends in the Assessment of Drug Supersaturation and Precipitation In Vitro Using Lipid-Based Delivery Systems
(2016)
Journal of Pharmaceutical Sciences
The generation of drug supersaturation close to the absorptive site is an important mechanism of how several formulation technologies enhance oral absorption and bioavailability. Lipid-based formulations belong to the ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Hydroxypropyl Cellulose for Drug Precipitation Inhibition: From the Potential of Molecular Interactions to Performance Considering Microrheology
(American Chemical Society, 2022-01-10)
Molecular Pharmaceutics
There has been recent interest in using hydroxypropyl cellulose (HPC) for supersaturating drug formulations. This study investigated the potential for molecular HPC interactions with the model drug celecoxib by integrating ...
01A - Beitrag in wissenschaftlicher Zeitschrift
In Silico, In Vitro, and In Vivo evaluation of precipitation inhibitors in supersaturated lipid-based formulations of venetoclax
(American Chemical Society, 2021-04-23)
Molecular Pharmaceutics
The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies
(2019-11-04)
Pharmaceutics
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin