Anzeige der Einträge 1-10 von 132
Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
Sedative and anxiolytic-like properties of flavonoids such as kaempferol and quercetin, and of some of their intestinal metabolites, have been demonstrated in pharmacological studies. However, routes of administration were ...
Evaluation of the intestinal absorption mechanism of casearin X in Caco-2 cells with Modified carboxylesterase activity
The clerodane diterpene casearin X (1), isolated from the leaves of Casearia sylvestris, is a potential new drug candidate due to its potent in vitro cytotoxic activity. In this work, the intestinal absorption mechanism ...
Pharmacokinetics and in vitro blood-brain barrier screening of the plant-derived alkaloid tryptanthrin
The indolo[2,1-b]quinazoline alkaloid tryptanthrin was previously identified as a potent anti-inflammatory compound with a unique pharmacological profile. It is a potent inhibitor of cyclooxygenase-2, 5-lipooxygenase-catalyzed ...
Outdoor fate and environmental impact of polymer solar cells through leaching and emission to rainwater and soil
The emission of silver and zinc to the aq. environment (rain, fog, dew) from polymer solar cells installed outdoors is presented. Studies included pristine solar cells and solar cells subjected to mech. damage under natural ...