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Supersaturated Lipid-Based Formulations to Enhance the Oral Bioavailability of Venetoclax
(Elsevier, 2020-06-18)
Pharmaceutics
Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. ...
01A - Beitrag in wissenschaftlicher Zeitschrift
In Silico, In Vitro, and In Vivo evaluation of precipitation inhibitors in supersaturated lipid-based formulations of venetoclax
(American Chemical Society, 2021-04-23)
Molecular Pharmaceutics
The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in ...
01A - Beitrag in wissenschaftlicher Zeitschrift