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Self-Assembling Peptide Matrix for treatment of dentin hypersensitivity: A randomized controlled clinical tria
Patient-reported dentin hypersensitivity [DHS] pain is a common finding linked with periodontal disease. This pilot clinical study investigates a novel therapeutic regimen using self-assembling peptide matrix [SAPM] gel ...
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules
Proximal tubules in the kidney play a crucial role in reabsorbing and eliminating substrates from the body into the urine, leading to high local concentrations of xenobiotics. This makes the proximal tubule a major target ...
Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition
Self-assembling peptide hydrogels can be modified regarding their biodegradability, their chemical and mechanical properties and their nanofibrillar structure. Thus, self-assembling peptide hydrogels might be suitable ...
Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro
The regeneration of tissue defects at the interface between soft and hard tissue, eg, in the periodontium, poses a challenge due to the divergent tissue requirements. A class of biomaterials that may support the regeneration ...
High-Throughput Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip
Drug-transporter interactions could impact renal drug clearance and should ideally be detected in early stages of drug development to avoid toxicity-related withdrawals in later stages. This requires reliable and robust ...
(Semi)‐Kontinuierliche Synthese von Produkten für die Pharma‐ oder Feinchemie in einem neuartigen Rohrreaktor im Pilotmaßstab
Viele potenziell gefa ̈hrliche chemische Re-aktionen lassen sich mit den derzeit in derpharmazeutischen Industrie u ̈blichenRu ̈hrkesselanlagen nicht inha ̈rent sicherdurchfu ̈hren. Aus diesem Grund wurdeein Projekt ...