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Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies
(Elsevier, 2021-04-04)
Journal of Pharmaceutical Sciences
Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Nephroscreen. A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment
(Elsevier, 2021-03)
Current Opinion in Toxicology
Proximal tubule epithelial cells are the main driver of renal transport and secretion of xenobiotics, making them susceptible to drug-induced kidney injury. Cell-based assays are a meaningful alternative to animal testing ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin
Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as fibrosis-specific extracellular biomarkers and promoters of HSC activation
(MDPI, 2021)
International Journal of Molecular Sciences
Liver fibrosis is characterized by the accumulation of extracellular matrix (ECM) resulting in the formation of fibrous scars. In the clinic, liver biopsies are the standard diagnostic method despite the potential for ...
01 - Zeitschriftenartikel, Journalartikel oder Magazin