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Mass transfer analysis and kinetic modeling for process design of countercurrent membrane supported reactive extraction of carboxylic acids

Schuur, Boelo; Gössi, Angelo; Riedl, Wolfgang (Elsevier, 2021)

Chemical Engineering Science: X

Countercurrent membrane supported reactive extraction (MSRE) was studied for removal of carboxylic acids from aqueous streams with a PTFE capillary membrane. Analysis of the mass transfer rates was per- formed to support ...

01A - Beitrag in wissenschaftlicher Zeitschrift

Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies

Suter-Dick, Laura; Caj, Michaela; Hutter, Simon; Vormann, Marianne; Vriend, Jelle; Lanz, Henriette; Gijzen, Linda; van den Heuvel, Angelique; Joore, Jos; Trietsch, Sebastian; Stuut, Christaan; Nieskens, Tom T.G.; Peters, Janny; Ramp, Daniela; Russel, Frans; Roth, Adrian; Lu, Shuyan; Polli, Joseph; Jacobsen, Björn (Elsevier, 2021-04-04)

Journal of Pharmaceutical Sciences

Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Stringent primer termination by an archaeo-eukaryotic DNA primase

Lipps, Georg; Bergsch, Jan; Devillier, Jean-Christophe; Jeschke, Gunnar (Frontiers, 2021-04-13)

Frontiers in Microbiology : Biology of archaea

Priming of single stranded templates is essential for DNA replication. In recent years, significant progress was made in understanding how DNA primase fulfils this fundamental function, particularly with regard to the ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Effect of a chronic Intake of the natural sweeteners Xylitol and Erythritol on glucose absorption in humans with obesity

Bordier, Valentine; Teysseire, Fabienne; Schlotterbeck, Götz; Beglinger, Christoph; Meyer-Gerspach, Anne-Christin; Wölnerhanssen, Bettina; Senner, Frank (MDPI, 2021-11-05)

nutrients

In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute in- gestion reduces ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Toothpastes with enzymes support gum health and reduce plaque formation

Paque, Pune; Schmidlin, Patrick; Wiedemeier, Daniel; Wegehaupt, Florian; Burrer, Phoebe; Körner, Philipp; Deari, Shengjile; Sciotti, Michel; Attin, Thomas (MDPI, 2021-01-19)

International Journal of Environmental Research and Public Health

Enzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study

Cuenod, Aline; Wüthrich, Daniel; Seth-Smith, Helena; Ott, Chantal; Gehringer, Christian; Foucaul, Frederic; Mouchet, Roxanne; Kassim, Ali; Revathi, Gunturu; Vogt, Deborah; von Felten, Stefanie; Bassetti, Stefano; Tschudin-Sutter, Sarah; Hettich, Timm; Schlotterbeck, Götz; Homberger, Christina; Casanova, Carlo; Moran-Gilad, Jakob; Sagi, Orli; Rodriguez-Sanchez, Belen; Müller, Franco; Aerni, Martina; Gaia, Valeria; van Dessel, Helke; Kampinga, Greetje; Müller, Claudia; Daubenberger, Claudia; Pflüger, Valentin; Egli, Adrian (Springer, 2021)

Genome Medicine

Background Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Membrane-supported liquid-liquid extraction. Where do we stand today?

Riedl, Wolfgang (Wiley, 2021-02)

ChemBioEng Reviews

Thanks to advances in materials science and manufacturing technology, membranes are now available for stable liquid-liquid extraction processes. Rigorous calculation models can be used to calculate the membrane areas ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

New Scale-up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants

Furrer, Thierry; Müller, Benedikt; Hasler, Christoph; Berger, Bernhard; Levis, Michael Karl; Zogg, Andreas (Swiss Chemical Society, 2021)

CHIMIA International Journal for Chemistry

The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Nephroscreen. A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment

Suter-Dick, Laura; Vriend, Jelle; Vormann, Marianne; Lanz, Henriette; Joore, Jos; Trietsch, Sebastian J.; Russel, Frans; Jacobsen, Björn; Roth, Adrian; Lu, Shuyan; Polli, Joseph; Naidoo, Anita; Masereeuw, Rosalinde; Wilmer, Martijn (Elsevier, 2021-03)

Current Opinion in Toxicology

Proximal tubule epithelial cells are the main driver of renal transport and secretion of xenobiotics, making them susceptible to drug-induced kidney injury. Cell-based assays are a meaningful alternative to animal testing ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as fibrosis-specific extracellular biomarkers and promoters of HSC activation

Suter-Dick, Laura; Messner, Catherine; Özkul, Dilek; Gaiser, Carine; Schmidt, Saskia; Terraciano, Luigi; Krähenbühl, Stephan (MDPI, 2021)

International Journal of Molecular Sciences

Liver fibrosis is characterized by the accumulation of extracellular matrix (ECM) resulting in the formation of fibrous scars. In the clinic, liver biopsies are the standard diagnostic method despite the potential for ...

01 - Zeitschriftenartikel, Journalartikel oder Magazin

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