Anzeige der Eintraege 1-2 von 2
Nrf2 protects stellate cells from Smad-dependent cell activation.
Hepatic stellate cells (HSC) orchestrate the deposition of extracellular matrix (ECM) and are the primary effector of liver fibrosis. Several factors, including TGF-β1, PDGF and oxidative stress, have been shown to trigger ...
Rat multicellular 3D liver microtissues to explore TGF-β1 induced effects
Chronic liver damage can lead to fibrosis, encompassing hepatocellular injury, activation of Kupffer cells (KC), and activation of hepatic stellate cells (HSC). Inflammation and TGF-β1 are known mediators in the liver ...