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Surface Immobilization and Shielding of a Transaminase Enzyme for the Stereoselective Synthesis of Pharmaceutically Relevant Building Blocks
Transaminases are enzymes capable of stereoselective reductive amination; they are of great interest in the production of chiral building blocks. However, the use of this class of enzymes in industrial processes is often ...
A Two‐Dimensional Polymer Synthesized at the Air/Water Interface
A trifunctional, partially fluorinated anthracene‐substituted triptycene monomer was spread at an air/water interface into a monolayer, which was transformed into a long‐range‐ordered 2D polymer by irradiation with a ...
Industrial Upscaling of DOPO-Based Phosphonamidates and Phosphonates Derivatives Using Cl2 Gas as a Chlorinating Agent
Herein, we report the industrial synthesis procedure of phosphonamidate and phosphonate derivatives via an efficient and simple chlorination of 9,10-dihydro-9-oxa-10-phosphaphenanthren-10-oxide (DOPO) with Cl2 gas. The key ...
Nrf2 protects stellate cells from Smad-dependent cell activation.
Hepatic stellate cells (HSC) orchestrate the deposition of extracellular matrix (ECM) and are the primary effector of liver fibrosis. Several factors, including TGF-β1, PDGF and oxidative stress, have been shown to trigger ...