Auflistung Institut für Pharma Technology nach Autor/Autorin "Alsenz, Jochem"
Anzeige der Einträge 1-9 von 9
-
A Systematic Study of Molecular Interactions of Anionic Drugs with a Dimethylaminoethyl Methacrylate Copolymer Regarding Solubility Enhancement
(2017)Molecular PharmaceuticsThe methacrylate-copolymer Eudragit EPO (EPO) has raised interest in solubility enhancement of anionic drugs. Effects on aqueous drug solubility at rather low polymer concentrations are barely known despite their importance ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Can we estimate the critical micelle concentration of amphiphilic drug bases from molecular connectivity indices?
(2017)Pharmaceutical Development and TechnologySelf-aggregation of drugs is since many years an important topic in the pharmaceutical sciences. Drugs can aggregate similar to surfactants and thereby exhibit a critical micelle concentration (CMC). The present work focused ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
From Quantum Chemistry to Prediction of Drug Solubility in Glycerides
(2019-11-04)Molecular Pharmaceutics01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Influence of Excipients on Solvent-Mediated Hydrate Formation of Piroxicam Studied by Dynamic Imaging and Fractal Analysis
(2015)Cryst. Growth Des.01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release
(2018-04)European Journal of Pharmaceutics and BiopharmaceuticsRecent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds. The current work studied ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Miniaturized X-ray powder diffraction assay (MixRay) for quantitative kinetic analysis of solvent-mediated phase transformations in pharmaceutics
(2016-11-30)Journal of Pharmaceutical and Biomedical AnalysisMany pharmaceutical compounds exhibit polymorphism, which may result in solvent-mediated phase transformations. Since the polymorphic form has an essential influence on physicochemical characteristics such as solubility ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
The quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state
(2017)European Journal of Pharmaceutical SciencesSolubility screening in different surfactant solutions is an important part of pharmaceutical profiling. A particular interest is in low surfactant concentrations that mimic the dilution of an oral dosage form. Despite of ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Theoretical Considerations of the Prigogine–Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts
(2016)Molecular PharmaceuticsDrug behavior in undercooled melts is highly important for pharmaceutics with regard to amorphous solid dispersions, and therefore, categories were recently introduced that differentiate glass formers (GFs) from other drugs ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Unexpected solubility enhancement of drug bases in presence of a dimethylaminoethyl methacrylate copolymer
(2017)Molecular PharmaceuticsThe methacrylate copolymer Eudragit EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple hydrophobic contacts with polymeric side chains. The latter type ...01 - Zeitschriftenartikel, Journalartikel oder Magazin