Auflistung Institut für Pharma Technology nach Titel
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In Silico, In Vitro, and In Vivo evaluation of precipitation inhibitors in supersaturated lipid-based formulations of venetoclax
(2021-04-23)Molecular PharmaceuticsThe concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review
(2018-06)Journal of Pharmacy and PharmacologyObjectives Drug precipitation in vivo poses a significant challenge for the pharmaceutical industry. During the drug development process, the impact of drug supersaturation or precipitation on the in vivo behaviour of ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
In vitro modulation of inflammatory target gene expression by a polyphenol-enriched fraction of rose oil distillation waste water
(2016)FitoterapiaClassical production of rose oil is based on water steam distillation from the flowers of Rosa damascena. During this process, large quantities of waste water accrue which are discharged to the environment, causing severe ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
In Vivo Performance of Innovative Polyelectrolyte Matrices for Hot Melt Extrusion of Amorphous Drug Systems
(2020)Molecular PharmaceuticsHot melt extrusion of amorphous systems has become a pivotal technology to cope with challenges of poorly water-soluble drugs. Previous research showed that small molecular additives with targeted molecular interactions ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Incorporation of HPMCAS during loading of glibenclamide onto mesoporous silica improves dissolution and inhibits precipitation
(2020-01)European Journal of Pharmaceutical SciencesMesoporous silica has emerged as an enabling formulation for poorly soluble active pharmaceutical ingredients (APIs). Unlike other formulations, mesoporous silica typically does not inhibit precipitation of supersaturated ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Influence of Excipients on Solvent-Mediated Hydrate Formation of Piroxicam Studied by Dynamic Imaging and Fractal Analysis
(2015)Cryst. Growth Des.01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Influence of salt type and ionic strength on self-assembly of dextran sulfate-ciprofloxacin nanoplexes
(2015)International Journal of PharmaceuticsWe evaluated an analytical setup to identify optimal preparation conditions for nanoplex formation of small molecule drugs and polyelectrolytes using ciprofloxacin (CIP) and dextran sulfate (DS) as model compounds. The ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release
(2018-04)European Journal of Pharmaceutics and BiopharmaceuticsRecent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds. The current work studied ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Introduction of the energy to break an avalanche as a promising parameter for powder flowability prediction
(2020-09-20)Powder TechnologyDynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder excipients, break energy (BE) is introduced as a new promising avalanche parameter. ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Investigating oral absorption of carbamazepine in paediatric populations
(2017)The AAPS JournalPrediction of the pharmacokinetics of orally administered drugs in children is of importance to optimize the efficacy and safety of pediatric medicines. Physiologically based pharmacokinetic (PBPK) models can be helpful ...01 - Zeitschriftenartikel, Journalartikel oder Magazin
