Zur Kurzanzeige

dc.contributor.authorSaal, Wiebke
dc.contributor.authorAlsenz, Jochem
dc.contributor.authorWyttenbach, Nicole
dc.contributor.authorKuentz, Martin
dc.date.accessioned2018-01-09T12:49:50Z
dc.date.available2018-01-09T12:49:50Z
dc.date.issued2017
dc.identifier.doi10.1016/j.ejps.2017.09.032
dc.identifier.urihttp://hdl.handle.net/11654/25768
dc.description.abstractSolubility screening in different surfactant solutions is an important part of pharmaceutical profiling. A particular interest is in low surfactant concentrations that mimic the dilution of an oral dosage form. Despite of intensive previous research on solubilization in micelles, there is only limited data available at low surfactant concentrations and generally missing is a physical state analysis of the residual solid. The present work therefore studied 13 model drugs in 6 different oral surfactant solutions (0.5%, w/w) by concomitant X-ray diffraction (XRPD) analysis to consider effects on solvent-mediated phase transformations. A particular aspect was potential occurrence of exceptionally high drug solubilization. As a result, general solubilization correlations were observed especially between surfactants that share chemical similarity. Exceptional solubility enhancement of several hundred-fold was evidenced in case of sodium dodecyl sulfate solutions with dipyridamole and progesterone. Furthermore, carbamazepine and testosterone showed surfactant-type dependent hydrate formation. The present results are of practical relevance for an optimization of surfactant screenings in preformulation and early development and provide a basis for mechanistic modeling of surfactant effects on solubilization and solid state modifications.
dc.language.isoen_US
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences
dc.accessRightsAnonymous
dc.subjectPoorly soluble drug
dc.subjectSurfactant; Solubilization
dc.subjectMicelles; Residual solid
dc.subjectSolvent-mediated phase transformation
dc.titleThe quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume111
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandYes
fhnw.pagination96-103
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


Dateien zu dieser Ressource

DateienGrösseFormatAnzeige

Zu diesem Eintrag gibt es keine Dateien.

Der Eintrag erscheint in:

Zur Kurzanzeige