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dc.contributor.authorSykora, Sabine
dc.contributor.authorCorrero, Maria Rita
dc.contributor.authorMoridi, Negar
dc.contributor.authorBelliot, Gaël
dc.contributor.authorPothier, Pierre
dc.contributor.authorDudal, Yves
dc.contributor.authorCorvini, Philippe
dc.contributor.authorShahgaldian, Patrick
dc.date.accessioned2018-01-23T08:28:17Z
dc.date.available2018-01-23T08:28:17Z
dc.date.issued2017
dc.identifier.doi10.1002/cbic.201700126
dc.identifier.urihttp://hdl.handle.net/11654/25888
dc.description.abstractThe design of nanomaterials that are capable of specific and sensitive biomolecular recognition is an on-going challenge in the chemical and biochemical sciences. A number of sophisticated artificial systems have been designed to specifically recognize a variety of targets. However, methods based on natural biomolecular detection systems using antibodies are often superior. Besides greater affinity and selectivity, antibodies can be easily coupled to enzymatic systems that act as signal amplifiers, thus permitting impressively low detection limits. The possibility to translate this concept to artificial recognition systems remains limited due to design incompatibilities. Here we describe the synthesis of a synthetic nanomaterial capable of specific biomolecular detection by using an internal biocatalytic colorimetric detection and amplification system. The design of this nanomaterial relies on the ability to accurately grow hybrid protein-organosilica layers at the surface of silica nanoparticles. The method allows for label-free detection and quantification of targets at picomolar concentrations.
dc.description.urihttp://onlinelibrary.wiley.com/doi/10.1002/cbic.201700126/full
dc.language.isoen_US
dc.relation.ispartofChemBioChem
dc.accessRightsAnonymous
dc.subjectBiocatalytic
dc.subjectnanomaterials
dc.subjectlabel-free detection
dc.subjectVirus-like Particles
dc.titleA Biocatalytic Nanomaterial for the Label-Free Detection of Virus-Like Particles
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume18
dc.issue11
dc.audiencePraxis
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination996-1000
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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