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dc.contributor.authorJankovic, Sandra
dc.contributor.authorTsakiridou, Georgia
dc.contributor.authorDitzinger, Felix
dc.contributor.authorKoehl, Niklas, J.
dc.contributor.authorPrice, Daniel
dc.contributor.authorIlie, Alexandra-Roxana
dc.contributor.authorKalantzi, Lida
dc.contributor.authorKimpe, Kristof
dc.contributor.authorHolm, Rene
dc.contributor.authorNair, Anita
dc.contributor.authorGriffin, Brendan
dc.contributor.authorSaal, Christoph
dc.contributor.authorKuentz, Martin
dc.date.accessioned2019-01-25T08:27:50Z
dc.date.available2019-01-25T08:27:50Z
dc.date.issued2018-07
dc.identifier.doihttps://doi.org/10.1111/jphp.12948
dc.identifier.urihttp://hdl.handle.net/11654/27329
dc.description.abstractObjectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water‐soluble drugs. Key findings An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches. In the pharmaceutical field, solubility parameters are primarily used to guide organic solvent selection, cocrystals and salt screening, lipid‐based delivery, solid dispersions and nano‐ or microparticulate drug delivery systems. Solubility parameters have been applied for a quantitative assessment of mixtures, or they are simply used to rank excipients for a given drug. Summary In particular, partial solubility parameters hold great promise for aiding the development of poorly soluble drug delivery systems. This is particularly true in early‐stage development, where compound availability and resources are limited. The experimental determination of solubility parameters has its merits despite being rather labour‐intensive because further data can be used to continuously improve in silico predictions. Such improvements will ensure that solubility parameters will also in future guide scientists in finding suitable drug formulations.
dc.description.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/jphp.12948
dc.language.isoen
dc.relation.ispartofJournal of Pharmacy and Pharmacology
dc.accessRightsAnonymous
dc.subjectenabling formulation
dc.subjectin silico prediction
dc.subjectpoorly water-soluble drug
dc.subjectsolubility parameter
dc.titleApplication of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review.
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume0
dc.issue0
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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