Application of the solubility parameter concept to assistwith oral delivery of poorly water-soluble drugs–a PEARRLreview
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ObjectivesSolubility parameters have been used for decades in various scientificfields including pharmaceutics. It is, however, still a field of active research bothon a conceptual and experimental level. This work addresses the need to reviewsolubility parameter applications in pharmaceutics of poorly water-soluble drugs.Key findingsAn overview of the different experimental and calculation methodsto determine solubility parameters is provided, which covers from classical tomodern approaches. In the pharmaceutical field, solubility parameters are pri-marily used to guide organic solvent selection, cocrystals and salt screening,lipid-based delivery, solid dispersions and nano- or microparticulate drug deliv-ery systems. Solubility parameters have been applied for a quantitative assessmentof mixtures, or they are simply used to rank excipients for a given drug.SummaryIn particular, partial solubility parameters hold great promise for aid-ing the development of poorly soluble drug delivery systems. This is particularlytrue in early-stage development, where compound availability and resources arelimited. The experimental determination of solubility parameters has its meritsdespite being rather labour-intensive because further data can be used to contin-uously improvein silicopredictions. Such improvements will ensure that solubil-ity parameters will also in future guide scientists in finding suitable drugformulations.