Zur Kurzanzeige

dc.contributor.authorGong, Yuhui
dc.contributor.authorNiederquell, Andreas
dc.contributor.authorKuentz, Martin
dc.date.accessioned2020-03-03T08:15:14Z
dc.date.available2020-03-03T08:15:14Z
dc.date.issued2019-09-09
dc.identifier.doi10.1021/acs.biomac.9b00867
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/30639
dc.description.abstractMonoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy their entire life, there is currently a great desire to formulate antibodies for bolus injection rather than infusion. However, to achieve the required doses, very concentrated antibody solutions may be required. Unfortunately, mAb/IgG self-assembly at high concentration can produce an unacceptably high viscosity for injection. To address this challenge, this study expands the concept of "dynamic covalent chemistry" to "dynamic bioconjugation" in order to reduce viscosity by interfering with antibody-antibody interactions. Ultra-sub-stoichiometric amounts of dynamic PEGylation agents (down to the nanomolar) significantly reduced the viscosity of concentrated antibody solutions by interfering with oligomerization.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pubmed/31398010en_US
dc.language.isoenen_US
dc.relation.ispartofBiomacromoleculesen_US
dc.accessRightsAnonymous*
dc.titleUltra-sub-stoichiometric “Dynamic” Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization.en_US
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin*
dc.volume20en_US
dc.issue9en_US
dc.audienceScienceen_US
fhnw.publicationStatePublisheden_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.InventedHereYesen_US
fhnw.PublishedSwitzerlandYesen_US
fhnw.pagination3557-3565en_US
fhnw.IsStudentsWorknoen_US
fhnw.publicationOnlineJaen_US


Dateien zu dieser Ressource

DateienGrösseFormatAnzeige

Zu diesem Eintrag gibt es keine Dateien.

Der Eintrag erscheint in:

Zur Kurzanzeige