Zur Kurzanzeige

dc.contributor.authorMoradi, Milad
dc.contributor.authorKuentz, Martin
dc.date.accessioned2021-05-10T06:42:52Z
dc.date.available2021-05-10T06:42:52Z
dc.date.issued2020-02-28
dc.identifier.doi10.1016/j.molliq.2020.112774
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/32417
dc.description.abstractThe solubility determination of 5-aminosalicylic acid (mesalazine) in the N-methyl-2-pyrrolidone (NMP)/ethanol mixtures was carried out at T = (293.2 to 313.2) K. The solubility data were represented by the Jouyban-Acree, NRTL and UNIQUAC models. Apparent thermodynamic quantities for mesalazine dissolved in NMP/ethanol mixtures were determined. To discuss solute-solvent interactions in the present system, the activity coefficient values for mesalazine were computed. The results revealed that the solubility increases by addition of NMP and reaches a maximum value at neat NMP which is consistent with the minimum values of both Gibbs free energy of dissolution and mesalazine activity coefficient observed at neat NMP. Moreover, this drug is preferentially solvated by ethanol in ethanol-rich mixtures but preferential solvation by NMP in NMP-rich mixtures is observed.en_US
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0167732220301161en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Molecular Liquidsen_US
dc.accessRightsAnonymous*
dc.subjectSolubilityen_US
dc.subjectN-methyl-2-pyrrolidoneen_US
dc.subjectMesalazine, activity coefficienten_US
dc.subjectPreferential solvationen_US
dc.titleSolubility of 5-aminosalicylic acid in {N-methyl-2-pyrrolidone + ethanol} mixtures at T = (293.2 to 313.2) Ken_US
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin*
dc.volume306en_US
dc.audienceScienceen_US
fhnw.publicationStatePublisheden_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.InventedHereYesen_US
fhnw.PublishedSwitzerlandYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.publicationOnlineJaen_US


Dateien zu dieser Ressource

DateienGrösseFormatAnzeige

Zu diesem Eintrag gibt es keine Dateien.

Der Eintrag erscheint in:

Zur Kurzanzeige