Schneider, Elia M.Raso, RenzoHofer, Corinne J.Zeltner, MartinStettler, Robert D.Hess, Samuel C.Grass, Robert N.Stark, Wendelin J.2024-09-132024-09-1320140022-32631520-690410.1021/jo501913zhttps://irf.fhnw.ch/handle/11654/47273Workup in organic synthesis can be very time-consuming, particularly when using reagents with both a solubility similar to that of the desired products and a tendency not to crystallize. In this respect, reactions involving organic bases would strongly benefit from a tremendously simplified separation process. Therefore, we synthesized a derivative of the superbasic proton sponge 1,8-bis(dimethylamino)naphthalene (DMAN) and covalently linked it to the strongest currently available nanomagnets based on carbon-coated cobalt metal nanoparticles. The immobilized magnetic superbase reagent was tested in Knoevenagel- and Claisen-Schmidt-type condensations and showed conversions of up to 99%. High yields of up to 97% isolated product could be obtained by simple recrystallization without using column chromatography. Recycling the catalyst was simple and fast with an insignificant decrease in catalytic activity.enCatalystsChemical reactionsCondensationNanoparticlesReagents500 - Naturwissenschaften und Mathematik01A - Beitrag in wissenschaftlicher Zeitschrift10908–10915