Cascino, PasqualeNevone, AlicePiscitelli, MaggieScopelliti, ClaudiaGirelli, MariaMazzini, GiuliaCaminito, SerenaRusso, GiancarloMilani, PaoloBasset, MarcoFoli, AndreaFazio, FrancescaCasarini, SimonaMassa, MargheritaBozzola, MargheritaRipepi, JessicaSesta, Melania AntoniettaAcquafredda, GloriaDe Cicco, MaricaMoretta, AntoniaRognoni, PaolaMilan, EnricoRicagno, StefanoLavatelli, FrancescaPetrucci, Maria TeresaKlersy, CatherineMerlini, GiampaoloPalladini, GiovanniNuvolone, MarioMiho, Enkelejda2023-02-092023-02-092022-08-230361-86091096-865210.1002/ajh.26684https://irf.fhnw.ch/handle/11654/34550Each patient with a monoclonal gammopathy has a unique monoclonal (M) protein, whose sequence can be used as a tumoral fingerprint to track the presence of the B cell or plasma cell (PC) clone itself. Moreover, the M protein can directly cause potentially life-threatening organ damage, which is dictated by the specific, patient's unique clonal light and/or heavy chain amino acid sequence, as in patients affected by immunoglobulin light chain (AL) amyloidosis.1 However, patients' specific M protein sequences remain mostly undefined and molecular mechanisms underlying M protein-related clinical manifestations are largely obscure.en600 - Technik, Medizin, angewandte Wissenschaften01A - Beitrag in wissenschaftlicher Zeitschrift