Single pollutant versus surrogate measure approaches: Do single pollutant risk assessments underestimate the impact of air pollution on lung cancer risk?

Röösli, MartinKünzli, NinoSchindler, ChristianTheis, GastonBayer-Oglesby, LucyMathys, PatrickCamenzind, MarkusBraun-Fahrländer, Charlotte2024-05-172024-05-1720031076-2752https://doi.org/10.1097/01.jom.0000079082.33909.c2https://irf.fhnw.ch/handle/11654/45826Cancer risk as a result of air pollution may be quantified by different approaches. We compared the sum of unit risk based effects of single pollutants with an epidemiology-based method by using PM10 as a surrogate of the total air pollution. The excess rate for lung cancer cases attributable to an increase of 10 μg/m3 in average PM10 exposure was estimated from available cohort studies. Applying the epidemiology-based risk method to the air pollution situation in the Basel area (Switzerland) resulted in 13.3 (95% CI = 6.9–19.8) excess lung cancer cases per 100,000 person years. This estimate was considerably higher than the unit risk-based estimate yielding 1.1 (range, 0.45–2.8) cancer cases per 100,000 person years. We discuss these discrepancies in light of inherent differences between approaches in toxicology and epidemiology.en624 - Ingenieurbau und Umwelttechnik610 - Medizin und GesundheitSingle pollutant versus surrogate measure approaches: Do single pollutant risk assessments underestimate the impact of air pollution on lung cancer risk?01A - Beitrag in wissenschaftlicher Zeitschrift715-723