de Wild, MichaelMolenberg, AartAmacher, FabienneChris, Bradbury2015-10-072015-10-072015-05-0710.1002/jbm.b.33419.http://hdl.handle.net/11654/10109Resorbable bone substitute materials are widely used for bone augmentation after tumor resection, parallel to implant placement, or in critical size bone defects. In this study, the structural dissolution of a biphasic calcium phosphate bone substitute material with a hydroxyapatite (HA)/tricalcium phosphate (ß-TCP) ratio of 60/40 was investigated by repeatedly placing porous blocks in EDTA solution at 37°C. At several time points, the blocks were investigated by SEM, µCT, and gravimetry. It was found that always complete 2–3 µm sized grains were removed from the structure and that the ß-TCP is dissolved more rapidly. This selective dissolution of the ß-TCP grains was confirmed by XRD measurements. The blocks were eroded from the outside toward the center. The structure remained mechanically stable because the central part showed a delayed degradation and because the slower dissolving HA grains preserved the integrity of the structure.enbioceramichydroxylapatiteß-TCPselective resorptionµCT/SEM/XRD610 - Medizin und Gesundheit01A - Beitrag in wissenschaftlicher Zeitschrift1-8