Correro, Maria RitaMoridi, NegarSchützinger, HansjörgSykora, SabineAmmann, ErikPeters, E. HenrikDudal, YvesCorvini, PhilippeShahgaldian, Patrick2016-10-212016-10-2120161521-37731433-78510570-083310.1002/anie.201600590http://hdl.handle.net/11654/23399The fragile nature of most enzymes is a major hindrance to their use in industrial processes. Herein, we describe a synthetic chem. strategy to produce hybrid org.​/inorg. nanobiocatalysts; it exploits the self-​assembly of silane building blocks at the surface of enzymes to grow an organosilica layer, of controlled thickness, that fully shields the enzyme. Remarkably, the enzyme triggers a rearrangement of this organosilica layer into a significantly soft structure. We demonstrate that this change in stiffness correlates with the biocatalytic turnover rate, and that the organosilica layer shields the enzyme in a soft environment with a markedly enhanced resistance to denaturing stresses.enFermentationBioindustrial Chemistry01A - Beitrag in wissenschaftlicher Zeitschrift6285–6289