Hradetzky, DavidMüller, ClaasReinecke, Holger2024-08-132024-08-1320050-7803-9278-72160-50332160-504110.1109/omems.2005.1540087https://irf.fhnw.ch/handle/11654/46769This work presents a simple evanescent wave sensing system based on an interferometric approach suitable to meet the demands on label free sensor systems for the detection of biomolecular interactions especially. It is representing a basic concept towards high throughput application. The system performance and reproducibility was evaluated with refractometric measurements of sucrose dilutions. A mean resolution of the effective refractive index of 3sigma(Deltamacrnmacr eff )=0.9middot10 -6 without averaging and a reproducibility below sigma r =0.1middot10 -6 were achieved. The suitability for the detection of biomolecular interactions was validated with the detection of a DNA hybridizationen600 - Technik, Medizin, angewandte Wissenschaften04B - Beitrag Konferenzschrift81-82