Ilko, DavidPuhl, SebastianMeinel, LorenzGermershaus, OliverHolzgrabe, Ulrike2015-12-222015-12-222015-020731-70851873-264Xhttps://doi.org/10.1016/j.jpba.2014.11.012http://hdl.handle.net/11654/11961Currently, neither the European nor the United States Pharmacopoeia provide a method for the determination of polidocanol (PD) content despite the fact that PD, besides being an excipient, is also used as an active pharmaceutical ingredient. We therefore developed a method where the PD content was determined using a Kinetex C18 column operated at 40°C with water-acetonitrile (15:85, v/v) as mobile phase. A Corona(®) charged aerosol detector was employed for the detection of PD that is lacking a suitable UV chromophore. The method was fully validated. Additionally, the method was applied for the determination of PD release from a pharmaceutical polymer matrix consisting of poly-ɛ-caprolactone and poly(lactic-co-glycolic acid) and PD.enAssayCharged aerosol detectionDissolutionHigh performance liquid chromatographyPharmaceutical analysisPolidocanol01A - Beitrag in wissenschaftlicher Zeitschrift17-20