Gaugler, StephanRykl, JanaWagner, Irenevon Däniken, TamaraFingerhut, RalphSchlotterbeck, Götz2018-12-132018-12-132017-122409-515Xhttps://doi.org/10.3390/ijns4010002http://hdl.handle.net/11654/26974A new and fully automated newborn screening method for mass spectrometry was introduced in this paper. Pathological relevant amino acids, acylcarnitines, and certain steroids are detected within 4 min per sample. Each sample is treated in an automated and standardized workflow, where a mixture of deuterated internal standards is sprayed onto the sample before extraction. All compounds showed good linearity, and intra- and inter-day variation lies within the acceptance criteria (except for aspartic acid). The described workflow decreases analysis cost and labor while improving the sample traceability towards good laboratory practice.ennewborn screening (NBS)dried blood spots (DBS)automation01A - Beitrag in wissenschaftlicher Zeitschrift