Hradetzky, DavidGazdhar, AmiqRuzgys, PauliusBöhringer, StephanSila Dokumaci, AyseHari, YvonneSchürch, ChristianBrühl, FridoSchürch, StefanSönke, SzidatRiether, CarstenSatkauskas, SauliusGeiser, Thomas2022-03-142022-03-142021-04-211663-981210.3389/fphar.2021.643492https://irf.fhnw.ch/handle/11654/33350https://doi.org/10.26041/fhnw-4131An advanced stage, centrally localized invasive tumor is a major cause of sudden death in lung cancer patients. Currently, chemotherapy, radiotherapy, laser ablation, or surgical resection if possible are the available state-of-the-art treatments but none of these guarantee remedy or long-term relief and are often associated with fatal complications. Allowing localized chemotherapy, by direct and confined drug delivery only at the tumor site, could be a promising option for preoperative down staging or palliative therapy. Here we report the localized and targeted application of intra tumor delivery of chemotherapeutics using a novel device based on the principle of electrospray.en-USAttribution 3.0 United StatesOcalized and targeted therapyElectrosprayNovel cancer treatmentCoulomb repulsionLocalized tumor treatment01A - Beitrag in wissenschaftlicher Zeitschrift