Miho, Enkelejda

Miho

Enkelejda

Miho, Enkelejda

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Sequencing of the M protein. Toward personalized medicine in monoclonal gammopathies
(Wiley, 23.08.2022) Cascino, Pasquale; Nevone, Alice; Piscitelli, Maggie; Scopelliti, Claudia; Girelli, Maria; Mazzini, Giulia; Caminito, Serena; Russo, Giancarlo; Milani, Paolo; Basset, Marco; Foli, Andrea; Fazio, Francesca; Casarini, Simona; Massa, Margherita; Bozzola, Margherita; Ripepi, Jessica; Sesta, Melania Antonietta; Acquafredda, Gloria; De Cicco, Marica; Moretta, Antonia; Rognoni, Paola; Milan, Enrico; Ricagno, Stefano; Lavatelli, Francesca; Petrucci, Maria Teresa; Klersy, Catherine; Merlini, Giampaolo; Palladini, Giovanni; Nuvolone, Mario; Miho, Enkelejda [in: American Journal of Hematology]
Each patient with a monoclonal gammopathy has a unique monoclonal (M) protein, whose sequence can be used as a tumoral fingerprint to track the presence of the B cell or plasma cell (PC) clone itself. Moreover, the M protein can directly cause potentially life-threatening organ damage, which is dictated by the specific, patient's unique clonal light and/or heavy chain amino acid sequence, as in patients affected by immunoglobulin light chain (AL) amyloidosis.1 However, patients' specific M protein sequences remain mostly undefined and molecular mechanisms underlying M protein-related clinical manifestations are largely obscure.
01A - Beitrag in wissenschaftlicher Zeitschrift