Shahgaldian, Patrick

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Shahgaldian
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Patrick
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Shahgaldian, Patrick

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2021 - 20234
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Enddatum: 2023 × Anfangsdatum: 2020 × Dateien dazu vorhanden?: Nein ×

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Gerade angezeigt 1 - 4 von 4
  • Vorschaubild nicht verfügbar
    Publikation
    Development and validation of a liquid chromatography-triple quadrupole mass spectrometry method for the determination of isopeptide ε-(γ-glutamyl) lysine in human urine as biomarker for transglutaminase 2 cross-linked proteins
    (Elsevier, 21.06.2023) Dejager, Lien; Jairaj, Mark; Jones, Kieran; Johnson, Timothy; Dudal, Sherri; Dudal, Yves; Shahgaldian, Patrick; Correro, Rita; Qu, Jun; An, Bo; Lucey, Richard; Szarka, Szabolcs; Wheller, Robert; Pruna, Alina; Kettell, Sarah; Pitt, Andrew; Cutler, Paul [in: Journal of Chromatography A]
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild nicht verfügbar
    Publikation
    Coordination-driven monolayer-to-bilayer transition in two-dimensional metal–organic networks
    (American Chemical Society, 16.03.2021) Moradi, Mina; Lengweiler, Nadia; Housecroft, Catherine; Tulli, Ludovico; Stahlberg, Henning; Jung, Thomas; Shahgaldian, Patrick [in: The Journal of Physical Chemistry Part B]
    We report on monolayer-to-bilayer transitions in 2D metal–organic networks (MONs) from amphiphiles supported at the water–air interface. Functionalized calix[4]arenes are assembled through the coordination of selected transition metal ions to yield monomolecular 2D crystalline layers. In the presence of Ni(II) ions, interfacial self-assembly and coordination yields stable monolayers. Cu(II) promotes 2D coordination of a monolayer which is then diffusively reorganizing, nucleates, and grows a progressive amount of second layer islands. Atomic force microscopic data of these layers after transfer onto solid substrates reveal crystalline packing geometries with submolecular resolution as they are varying in function of the building blocks and the kinetics of the assembly. We assign this monolayer-to-bilayer transition to a diffusive reorganization of the initial monolayers owing to chemical vacancies of the predominant coordination motif formed by Cu2+ ions. Our results introduce a new dimension into the controlled monolayer-to-multilayer architecturing of 2D metal–organic networks.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild nicht verfügbar
    Publikation
    Spectrophotometric study of the interaction of active pharmaceutical ingredients with colloidal silver nanoparticles capped by sulfonato-calix[6]arene derivatives
    (Taylor & Francis, 13.02.2021) Montasser, Imed; Robert, Paul; Hafiane, Amor; Correro, Maria Rita; Shahgaldian, Patrick [in: Materials Technology]
    Three sulfonato-calix[6]arene derivatives, namely para-sulfonato-calix[6]arene, calix[6]arene-O-propyl-3-sulphonate and para-sulfonato-calix[6]arene-O-propyl-3-sulphonate have been used as capping agents for silver nanoparticles. The sulfonato-calix[6]arene derivatives were demonstrated to stabilise the nanoparticles, and to act as ligands for molecular recognition at the surface of the nanoparticles. The nanoparticles were characterised by UV-visible spectroscopy, dynamic light scattering, zeta potential and scanning electron microscopy. The localised surface plasmon resonance of the nanoparticles was shown to be highly sensitive to the local environment, and was used to evaluate molecular interactions with four active pharmaceutical ingredients: streptomycin, gentamycin, D-penicillamine and chloramphenicol. Changes in spectral intensity and wavelength have shown that the interactions are dependent on both the nature of the active pharmaceutical ingredient and that of the calix[6]arene receptor.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild nicht verfügbar
    Publikation
    Immobilisation and stabilisation of glycosylated enzymes on boronic acid-functionalised silica nanoparticles
    (Royal Society of Chemistry, 2021) Nazemi, Seyed; Olesinska, Magdalena; Pezzella, Cinzia; Varriale, Simona; Lin, Chia-Wei; Corvini, Philippe; Shahgaldian, Patrick [in: Chemical Communications]
    We report a method of glycosylated enzymes’ surface immobilisation and stabilisation. The enzyme is immobilised at the surface of silica nanoparticles through the reversible covalent binding of vicinal diols of the enzyme glycans with a surface-attached boronate derivative. A soft organosilica layer of controlled thickness is grown at the silica surface, entrapping the enzyme and thus avoiding enzyme leaching. We demonstrate that this approach results not only in high and durable activity retention but also enzyme stabilisation.
    01A - Beitrag in wissenschaftlicher Zeitschrift