A Versatile Biocompatible Antibiotic Delivery System Based on Self‐Assembling Peptides with Antimicrobial and Regenerative Potential

dc.accessRightsAnonymous*
dc.audienceScienceen_US
dc.contributor.authorKoch, Franziska
dc.contributor.authorKilian, David
dc.contributor.authorHettich, Timm
dc.contributor.authorGermershaus, Oliver
dc.date.accessioned2020-03-03T08:47:06Z
dc.date.available2020-03-03T08:47:06Z
dc.date.issued2019-04-15
dc.description.abstractPeriodontitis is a chronic inflammatory and tissue‐destructive disease. Since the polymicrobiome in the oral cavity makes it difficult to treat, novel therapeutic strategies are required. Hydrogels based on self‐assembling peptides (SAP) can be suitable candidates for periodontal therapy due to their injectability, biocompatibility, cargo‐loading capacity, and tunable physicochemical and mechanical properties. In this study, two SAP hydrogels (P11‐4 and P11‐28/29) are examined for their intrinsic antimicrobial activity, regenerative potential, and antibiotic delivery capacity. A significant antibacterial effect of P11‐28/29 hydrogels on the periodontal pathogen Porphyromonas gingivalis and a less pronounced effect for P11‐4 hydrogels is demonstrated. The metabolic activity rates of human dental follicle stem cells (DFSCs), which reflect cell viability and may thus indicate the regenerative capacity, are similar on tissue culture polystyrene (TCPS) and on P11‐4 hydrogels after 14 days of culture. Noticeably, both SAP hydrogels strengthen the osteogenic differentiation of DFSCs compared with TCPS. The incorporation of tetracycline, ciprofloxacin, and doxycycline does not affect fibril formation of either SAP hydrogel and results in favorable release kinetics up to 120 h. In summary, this study reveals that P11‐SAP hydrogels combine many favorable properties required to make them applicable as prospective novel treatment strategy for periodontal therapy.en_US
dc.identifier.doi10.1002/adhm.201900167
dc.identifier.issn2192-2640
dc.identifier.issn2192-2659
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/30650
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAdvanced Healthcare Materialsen_US
dc.subjectantibiotic deliveryen_US
dc.subjectantimicrobial activityen_US
dc.subjectdental stem cellsen_US
dc.subjectperiodontal diseaseen_US
dc.subjectself‐assembling peptidesen_US
dc.titleA Versatile Biocompatible Antibiotic Delivery System Based on Self‐Assembling Peptides with Antimicrobial and Regenerative Potentialen_US
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dspace.entity.typePublication
fhnw.InventedHereYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.PublishedSwitzerlandYesen_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Chemie und Bioanalytikde_CH
fhnw.publicationOnlineJaen_US
fhnw.publicationStatePublisheden_US
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relation.isAuthorOfPublication.latestForDiscoverye5fa805a-8b20-45f1-9028-87076d04b044
Dateien