Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit
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Autor:innen
Kyrill, Maier
Thoma, Daniel
Bredell, Marius
Kruse, Astrid
Grätz, Klaus
Weber, Franz
Autor:in (Körperschaft)
Publikationsdatum
2013
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Tissue Engineering. Part A
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
19
Ausgabe / Nummer
23-24
Seiten / Dauer
2645-54
Patentnummer
Verlag / Herausgebende Institution
Mary Ann Liebert
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The treatment of large bone defects still poses a major challenge in orthopaedic and cranio-maxillofacial surgery. One possible solution could be the development of personalized porous titanium-based implants that are designed to meet all mechanical needs with a minimum amount of titanium and maximum osteopromotive properties so that it could be combined with growth factor-loaded hydrogels or cell constructs to realize advanced bone tissue engineering strategies. Such implants could prove useful for mandibular reconstruction, spinal fusion, the treatment of extended long bone defects, or to fill in gaps created on autograft harvesting. The aim of this study was to determine the mechanical properties and potential of bone formation of light weight implants generated by selective laser melting (SLM). We mainly focused on osteoconduction, as this is a key feature in bone healing and could serve as a back-up for osteoinduction and cell transplantation strategies. To that end, defined implants were produced by SLM, and their surfaces were left untreated, sandblasted, or sandblasted/acid etched. In vivo bone formation with the different implants was tested throughout calvarial defects in rabbits and compared with untreated defects. Analysis by micro computed tomography (µCT) and histomorphometry revealed that all generatively produced porous Ti structures were well osseointegrated into the surrounding bone. The histomorphometric analysis revealed that bone formation was significantly increased in all implant-treated groups compared with untreated defects and significantly increased in sand blasted
implants compared with untreated ones. Bone bridging was significantly increased in sand blasted acid-etched scaffolds. Therefore, scaffolds manufactured by SLM should be surface treated. Bone augmentation beyond the original bone margins was only seen in implant-treated defects, indicating an osteoconductive potential of the implants that could be utilized clinically for bone augmentation purposes. Therefore, designed porous, lightweight structures have potential for bone regeneration and augmentation purposes, especially when complex and patient-specific geometries are essential.
Schlagwörter
slm, bone ingrowth, Osteoconductivity
Fachgebiet (DDC)
570 - Biowissenschaften, Biologie
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1937-335X
1937-3341
1937-3341
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Lizenz
Zitation
DE WILD, Michael, Ralf SCHUMACHER, Maier KYRILL, Erik SCHKOMMODAU, Daniel THOMA, Marius BREDELL, Astrid KRUSE, Klaus GRÄTZ und Franz WEBER, 2013. Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit. Tissue Engineering. Part A. 2013. Bd. 19, Nr. 23-24, S. 2645–54. DOI 10.1089/ten.TEA.2012.0753. Verfügbar unter: http://hdl.handle.net/11654/10110