Modeling-based approach towards quality by design for a telescoped process
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Autor:innen
Autor:in (Körperschaft)
Publikationsdatum
2024
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Chimia
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
78
Ausgabe / Nummer
3
Seiten / Dauer
135-141
Patentnummer
Verlag / Herausgebende Institution
Schweizerische Chemische Gesellschaft
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
A telescoped, two-step synthesis was investigated by applying Quality by Design principles. A kinetic model consisting of 12 individual reactions was successfully established to describe the synthesis and side reactions. The resulting model predicts the effects of changes in process parameters on total yield and quality. Contour plots were created by varying process parameters and displaying the model predicted process response. The areas in which the process response fulfils predetermined quality requirements are called design spaces. New ranges for process parameters were explored within these design spaces. New conditions were found that increased the robustness of the process and allowed for a considerable reduction of the used amounts of a reagent. Further optimizations, based on the newly generated knowledge, are expected. Improvements can either be direct process improvements or enhancements to control strategies. The developed strategies can also be applied to other processes, enhancing upcoming and preexisting research and development efforts.
Schlagwörter
Continuous process improvement, Kinetic modeling, Quality by design (QbD)
Fachgebiet (DDC)
500 - Naturwissenschaften und Mathematik
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
2673-2424
0009-4293
0009-4293
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Diamond
Lizenz
Zitation
ZAHND, This, Maja KANDZIORA, Michael K. LEVIS und Andreas ZOGG, 2024. Modeling-based approach towards quality by design for a telescoped process. Chimia. 2024. Bd. 78, Nr. 3, S. 135–141. DOI 10.2533/chimia.2024.135. Verfügbar unter: https://doi.org/10.26041/fhnw-8793