Auflistung nach Autor/Autorin "Saal, Wiebke"
Anzeige der Einträge 1-4 von 4
-
Can we estimate the critical micelle concentration of amphiphilic drug bases from molecular connectivity indices?
(2017)Pharmaceutical Development and TechnologySelf-aggregation of drugs is since many years an important topic in the pharmaceutical sciences. Drugs can aggregate similar to surfactants and thereby exhibit a critical micelle concentration (CMC). The present work focused ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Interactions of dimethylaminoethyl methacrylate copolymer with non-acidic drugs demonstrated high solubilization in vitro and pronounced sustained release
(2018-04)European Journal of Pharmaceutics and BiopharmaceuticsRecent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds. The current work studied ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
The quest for exceptional drug solubilization in diluted surfactant solutions and consideration of residual solid state
(2017)European Journal of Pharmaceutical SciencesSolubility screening in different surfactant solutions is an important part of pharmaceutical profiling. A particular interest is in low surfactant concentrations that mimic the dilution of an oral dosage form. Despite of ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Unexpected solubility enhancement of drug bases in presence of a dimethylaminoethyl methacrylate copolymer
(2017)Molecular PharmaceuticsThe methacrylate copolymer Eudragit EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple hydrophobic contacts with polymeric side chains. The latter type ...01 - Zeitschriftenartikel, Journalartikel oder Magazin