Auflistung nach Autor/Autorin "O'Dwyer, Patrick J."
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In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review
(2018-06)Journal of Pharmacy and PharmacologyObjectives Drug precipitation in vivo poses a significant challenge for the pharmaceutical industry. During the drug development process, the impact of drug supersaturation or precipitation on the in vivo behaviour of ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Novel Biphasic Lipolysis Method To Predict in Vivo Performance of Lipid-Based Formulations
(2020-08-21)Molecular PharmaceuticsThe absence of an intestinal absorption sink is a significant weakness of standard in vitro lipolysis methods, potentially leading to poor prediction of in vivo performance and an overestimation of drug precipitation. In ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state
(2022)European Journal of Pharmaceutical SciencesA small-scale two-stage biphasic system, a small-scale two-stage dissolution-permeation system, the Erweka mini-paddle apparatus, and the BioGIT system were evaluated for their usefulness in assessing the intraluminal ...01A - Beitrag in wissenschaftlicher Zeitschrift
