• Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review 

      Jankovic, Sandra; Tsakiridou, Georgia; Ditzinger, Felix; Koehl, Niklas; Price, Daniel; Ilie, Alexandra Roxana; Kalantzi, Lida; Kimpe, Kristof; Holm, Rene; Nair, Anita; Griffin, Brendan; Saal, Christoph; Kuentz, Martin (2018-07)
      Journal of Pharmacy and Pharmacology
      Objectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work ...
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    • Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations. A pilot study 

      Bennett-Lenane, Harriett; O'Shea, Joseph; Murray, Jack; Ilie, Alexandra Roxana; Holm, Rene; Kuentz, Martin; Griffin, Brendan (2021-09-05)
      pharmaceutics
      In response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent ...
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    • Current challenges and future perspectives in oral absorption research. An opinion of the UNGAP network 

      Kuentz, Martin; Vinarov, Zahari; Bertil, Abrahamsson; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnürch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Eide Flaten, Goril; Fotaki, Nikoleta; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Augustijns, Patrick; Griffin, Brendan (2021-04)
      Advanced Drug Delivery Reviews
      Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient ...
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    • Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated lipid-based drug delivery systems 

      Kuentz, Martin; Ilie, Alexandra Roxana; Griffin, Brendan; Vertzoni, Maria; Kolakovic, Ruzica; Prudic-Paus, Anke; Malash, Ahmed; Bohets, Hugo; Herman, Jilly; Holm, Rene (2021-04-01)
      European Journal of Pharmaceutical Sciences
      Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorlywater-soluble drugs. While increasing the drug load ...
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    • In Silico, In Vitro, and In Vivo evaluation of precipitation inhibitors in supersaturated lipid-based formulations of venetoclax 

      Koehl, Niklas; Henze, Laura; Bennett-Lenane, Harriett; Faisal, Waleed; Price, Daniel J.; Holm, Rene; Kuentz, Martin; Griffin, Brendan (2021-04-23)
      Molecular Pharmaceutics
      The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in ...
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    • Lipophilic salts and lipid-based formulations for bridging the food effect gap of venetoclax 

      Koehl, Niklas; Henze, Laura; Holm, Rene; Kuentz, Martin; Keating, John; De Vijlder, Thomas; Marx, Andreas; Griffin, Brendan (2022-01)
      Pharmaceutics, Drug Delivery and Pharmaceutical Technology
      Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF ...
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    • Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches | a PEARRL review 

      Ditzinger, Felix; Price, Daniel J.; Ilie, Alexandra Roxana; Koehl, Niklas; Jankovic, Sandra; Tsakiridou, Georgia; Aleandri, Simone; Kalantzi, Lida; Holm, Rene; Nair, Anita; Saal, Christoph; Griffin, Brendan; Kuentz, Martin (2019-04)
      Journal of Pharmacy and Pharmacology
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    • Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review 

      Ditzinger, Felix; Price, Daniel; Ilie, Alexandra Roxana; Koehl, Niklas; Jankovic, Sandra; Tsakiridou, Georgia; Aleandri, Simone; Kalantzi, Lida; Holm, Rene; Nair, Anita; Saal, Christoph; Griffin, Brendan; Kuentz, Martin (2018-08)
      Journal of Pharmacy and Pharmacology
      Objectives This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided ...
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    • Rational selection of bio-enabling oral drug formulations. A PEARRL commentary 

      Kuentz, Martin; Kronseder, Christian; Holm, Rene; Saal, Christoph; Griffin, Brendan (2021-05)
      Journal of Pharmaceutical Sciences
      New drug candidates often require bio-enabling formation technologies such as lipid-based formulations, solid dispersions, or nanosized drug formulations. Development of such more sophisticated delivery systems generally ...
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