Auflistung nach Autor/Autorin "Niederquell, Andreas"
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Machine Estimation of Drug Melting Properties and Influence on Solubility Prediction
Wyttenbach, Nicole; Niederquell, Andreas; Kuentz, Martin (2020-06-04)There has been much recent interest in machine learning (ML) and molecular quantitative structure property relationships (QSPR). The present research evaluated modern ML-based methods implemented in commercial software ... -
Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
Vraníková, Barbora; Niederquell, Andreas; Ditzinger, Felix; Kuentz, Martin (2020-01-30) -
Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics
Niederquell, Andreas; Kuentz, Martin (2019-01-04)Partial solvation parameters (PSP) have much in common with the Hansen solubility parameter or with a linear solvation energy relationship (LSER), but there are advantages based on the sound thermodynamic basis. It is, ... -
A Relative Permittivity Approach for Fast Drug Solubility Screening of Solvents and Excipients in Lipid-Based Delivery.
Niederquell, Andreas; Kuentz, Martin (2019)Drug solubility screening in solvents and lipids is central for the development of lipid-based formulations (LBFs), and any guidance to reduce the experimental workload would be highly desirable. Solubility parameters are ... -
Relevance of the theoretical critical pore radius in mesoporous silica for fast crystallizing drugs
Vraníková, Barbora; Niederquell, Andreas; Kuentz, Martin (2020-10-26)Formulation of poorly water-soluble drugs with mesoporous silica has become a thriving field of pharmaceutics. The theoretical critical pore diameter has been introduced as a maximum value below which an undesired drug ... -
Ultra-sub-stoichiometric “Dynamic” Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization.
Gong, Yuhui; Niederquell, Andreas; Kuentz, Martin (2019-09-09)Monoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy ...