Auflistung nach Autor/Autorin "Niederquell, Andreas"
Anzeige der Einträge 1-12 von 12
-
A diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment
Niederquell, Andreas; Machado, Alexandra H.E.; Kuentz, Martin (2017)International Journal of PharmaceuticsEmulsions are broadly used in pharmaceutics either as intermediate products or as final dosage forms. Such disperse systems are only kinetically stabilized and therefore early detection of physical instability is highly ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Biorelevant drug solubility enhancement modeled by a linear solvation energy relationship
Niederquell, Andreas; Kuentz, Martin (2017)Journal of Pharmaceutical SciencesIt is for the pharmaceutical sciences of vital importance to understand how drugs are solubilized in biorelevant media. However, the complexity of fasted state simulated intestinal fluid (FaSSIF) has so far hampered adequate ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Hydroxypropyl Cellulose for Drug Precipitation Inhibition: From the Potential of Molecular Interactions to Performance Considering Microrheology
Stoyanov, Edmont; Niederquell, Andreas; Kuentz, Martin (2022-01-10)Molecular PharmaceuticsThere has been recent interest in using hydroxypropyl cellulose (HPC) for supersaturating drug formulations. This study investigated the potential for molecular HPC interactions with the model drug celecoxib by integrating ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Machine Estimation of Drug Melting Properties and Influence on Solubility Prediction
Wyttenbach, Nicole; Niederquell, Andreas; Kuentz, Martin (2020-06-04)Molecular PharmaceuticsThere has been much recent interest in machine learning (ML) and molecular quantitative structure property relationships (QSPR). The present research evaluated modern ML-based methods implemented in commercial software ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
Vraníková, Barbora; Niederquell, Andreas; Ditzinger, Felix; Kuentz, Martin (2020-01-30)International Journal of Pharmaceutics01 - Zeitschriftenartikel, Journalartikel oder Magazin -
New prediction methods for solubility parameters based on molecular sigma profiles using pharmaceutical materials
Niederquell, Andreas; Wyttenbach, Nicole; Kuentz, Martin (2018-07)International Journal of PharmaceuticalsSolubility parameters have been applied extensively in the chemical and pharmaceutical sciences. Particularly attractive is calculation of solubility parameters based on chemical structure and recently, new in silico methods ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Partial Solvation Parameters of Drugs as a New Thermodynamic Tool for Pharmaceutics
Niederquell, Andreas; Kuentz, Martin (2019-01-04)PharmaceuticsPartial solvation parameters (PSP) have much in common with the Hansen solubility parameter or with a linear solvation energy relationship (LSER), but there are advantages based on the sound thermodynamic basis. It is, ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
A Relative Permittivity Approach for Fast Drug Solubility Screening of Solvents and Excipients in Lipid-Based Delivery
Niederquell, Andreas; Kuentz, Martin (2019)Journal of Pharmaceutical SciencesDrug solubility screening in solvents and lipids is central for the development of lipid-based formulations (LBFs), and any guidance to reduce the experimental workload would be highly desirable. Solubility parameters are ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Relevance of the theoretical critical pore radius in mesoporous silica for fast crystallizing drugs
Vraníková, Barbora; Niederquell, Andreas; Kuentz, Martin (2020-10-26)International Journal of PharmaceuticsFormulation of poorly water-soluble drugs with mesoporous silica has become a thriving field of pharmaceutics. The theoretical critical pore diameter has been introduced as a maximum value below which an undesired drug ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Study and computational modeling of fatty acid effects on drug solubility in lipid-based systems
Wyttenbach, Nicole; Ectors, Philipp; Niederquell, Andreas; Kuentz, Martin (2022-06)Journal of Pharmaceutical SciencesLipid-based systems have many advantages in formulation of poorly water-soluble drugs but issues of a limited solvent capacity are often encountered in development. One of the possible solubilization approaches of especially ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Temperature-Induced Surface Effects on Drug Nanosuspensions
Aleandri, Simone; Schönenberger, Monica; Niederquell, Andreas; Kuentz, Martin (2018-02)Pharmaceutical ResearchPurpose The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Ultra-sub-stoichiometric “Dynamic” Bioconjugation Reduces Viscosity by Disrupting Immunoglobulin Oligomerization
Gong, Yuhui; Niederquell, Andreas; Kuentz, Martin (2019-09-09)BiomacromoleculesMonoclonal antibodies (mAb) are a major focus of the pharmaceutical industry, and polyclonal immunoglobulin G (IgG) therapy is used to treat a wide variety of health conditions. As some individuals require mAb/IgG therapy ...01 - Zeitschriftenartikel, Journalartikel oder Magazin