• Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study 

      Suter-Dick, Laura; Mauch, Linda; Caj, Michaela; Vormann, Marianne K.; Hutter, Simon; Lanz, Henriette; Wilmer, Martijn; Ramp, Daniela; Masereeuw, Rosalinde; Vriend, Jelle (2018-07)
      The APPS Journal
      Drug-induced kidney injury is often observed in the clinics and can lead to long-term organ failure. In this work, we evaluated a novel in vitro system that aims at detecting whether compounds can cause renal proximal ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • High-Throughput Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip 

      Vriend, Jelle; Nieskens, Tom T.G.; Vormann, Marianne K.; van den Berge, Batholomeus T.; van den Heuvel, Angelique; Russel, Frans G.M.; Suter-Dick, Laura; Lanz, Henriette; Vulto, Paul; Masereeuw, Rosalinde; Wilmer, Martijn (2018-07)
      The APPS Journal (An official Journal of the American Association of Pharmaceutical Scientists)
      Drug-transporter interactions could impact renal drug clearance and should ideally be detected in early stages of drug development to avoid toxicity-related withdrawals in later stages. This requires reliable and robust ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies 

      Suter-Dick, Laura; Caj, Michaela; Hutter, Simon; Vormann, Marianne; Vriend, Jelle; Lanz, Henriette; Gijzen, Linda; van den Heuvel, Angelique; Joore, Jos; Trietsch, Sebastian; Stuut, Christaan; Nieskens, Tom T.G.; Peters, Janny; Ramp, Daniela; Russel, Frans; Roth, Adrian; Lu, Shuyan; Polli, Joseph; Jacobsen, Björn (2021-04-04)
      Journal of Pharmaceutical Sciences
      Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Nephroscreen. A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment 

      Suter-Dick, Laura; Vriend, Jelle; Vormann, Marianne; Lanz, Henriette; Joore, Jos; Trietsch, Sebastian J.; Russel, Frans; Jacobsen, Björn; Roth, Adrian; Lu, Shuyan; Polli, Joseph; Naidoo, Anita; Masereeuw, Rosalinde; Wilmer, Martijn (2021-03)
      Current Opinion in Toxicology
      Proximal tubule epithelial cells are the main driver of renal transport and secretion of xenobiotics, making them susceptible to drug-induced kidney injury. Cell-based assays are a meaningful alternative to animal testing ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules 

      Vormann, Marianne K.; Gijzen, Linda; Hutter, Simon; Boot, Lisette; Nicolas, Arnaud; van den Heuvel, Angelique; Vriend, Jelle; Ng, Chee Ping; Nieskens, Tom T.G.; van Duinen, Vincent; de Wagenaar, Bjorn; Masereeuw, Rosalinde; Suter-Dick, Laura; Trietsch, Sebastian J.; Wilmer, Martijn; Joore, Jos; Vulto, Paul; Lanz, Henriette (2018-08)
      The APPS Journal
      Proximal tubules in the kidney play a crucial role in reabsorbing and eliminating substrates from the body into the urine, leading to high local concentrations of xenobiotics. This makes the proximal tubule a major target ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin