• Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone 

      Jähne, Evelyn A.; Eigenmann, Daniela E.; Moradi-Afrapoli, Fahimeh; Verjee, Sheela; Butterweck, Veronika; Hebeisen, Simon; Hettich, Timm; Schlotterbeck, Götz; Smiesko, Martin; Hamburger, Matthias; Oufir, Mouhssin (2016)
      Planta Medica
      Tryptanthrin and (E,​Z)​-​3-​(4-​hydroxy-​3,​5-​dimethoxybenzylidene)​indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-​inflammatory and antiallergic alkaloids, and shown to inhibit COX-​2, ...
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    • Development and full validation of an UPLC-MS/MS method for the quantification of the plant-derived alkaloid indirubin in rat plasma 

      Jähne, Evelyn A.; Butterweck, Veronika; Hamburger, Matthias; Oufir, Mouhssin; Sampath, Chethan (2016)
      Journal of Pharmaceutical and Biomedical Analysis
      An UPLC-MS/MS method for the quantification of indirubin in lithium heparinized rat plasma was developed and validated according to current international guidelines. Indirubin was extracted from rat plasma by using Waters ...
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    • Pharmacokinetics and in vitro blood-brain barrier screening of the plant-derived alkaloid tryptanthrin 

      Jähne, Evelyn A.; Eigenmann, Daniela E.; Sampath, Chethan; Butterweck, Veronika; Culot, Maxime; Cecchelli, Roméo; Gosselet, Fabien; Walter, Fruzsina R.; Deli, Maria A.; Smiesko, Martin; Hamburger, Matthias; Oufir, Mouhssin (2016)
      Planta Medica
      The indolo[2,1-b]quinazoline alkaloid tryptanthrin was previously identified as a potent anti-inflammatory compound with a unique pharmacological profile. It is a potent inhibitor of cyclooxygenase-2, 5-lipooxygenase-catalyzed ...
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