Anzeige der Einträge 1-18 von 18

    • A UHPLC–MS/MS method for the quantification of 7α-hydroxy-4-cholesten-3-one to assist in diagnosis of bile acid malabsorption 

      Prost, Jean-Christophe; Brunner, Félix; Grob, Christian; Berchtold, Christian; Schlotterbeck, Götz; Bovet, Cédric; Largiadèr, Carlo R.; Fiedler, Georg Martin; Juillerat, Pascal (2017-01)
      Clinical Mass Spectrometry
      Bile acids malabsorption (BAM) is encountered in numerous gastrointestinal pathologies and is a good example of a treatable cause of watery diarrhea after ileal resection. The gold standard for diagnosing BAM is the selenium ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Altered (neo-) lacto series glycolipid biosynthesis impairs α2-6 sialylation on N-glycoproteins in ovarian cancer cells 

      Alam, Shahidul; Anugraham, Merrina; Huang, Yen-Lin; Kohler, Reto; Hettich, Timm; Winkelbach, Katharina; Grether, Yasmin; Nunez Lopez, Monica; Khasbiullina, Nailia; Bovin, Nicolai V.; Schlotterbeck, Götz; Jacob, Francis (2017-03-30)
      Scientific Reports
      The (neo-) lacto series glycosphingolipids (nsGSLs) comprise of glycan epitopes that are present as blood group antigens, act as primary receptors for human pathogens and are also increasingly associated with malignant ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • An Acute Ocfentanil Fatality: A Case Report with Postmortem Concentrations 

      Dussy, Franz; Hangartner, Sarah; Hamberg, Cornelia; Berchtold, Christoph; Scherer, Ulrich; Schlotterbeck, Götz; Wyler, David; Briellmann, Thomas (2016)
      Journal of Analytical Toxicology
      A 24-year-old man known to consume illegal drugs was found dead in his apartment. A reclosable plastic zipper bag containing several hundred milligrams of a brown powder was found close to the dead body and the first ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Antimicrobial Polyethylene through Melt Compounding with Quaternary Ammonium Salts 

      Rossetti, Fernanda; Siegmann, Konstantin; Köser, Joachim; Wegner, Irene; Keskin, Ismail; Schlotterbeck, Götz; Winkler, Martin (2017-04)
      International Journal of Polymer Science
      Selected mono- and bicationic quats were compounded with polyethylene. The physicochemical surface properties, leaching behavior, and antibacterial activity of such modified samples were investigated. Contact angle ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Automated chiral method screening. Evaluation of generated chromatographic data sets to further optimize screening efficiency 

      Freund, Ernst; Meyer, Daniel; Schneider, Nadine; Lozach, Marie-Anne; Schröder, Harald; Cinar, Catagay; Schlotterbeck, Götz; Wagner, Trixie (2021-05-10)
      Journal of Chromatography A
      We set up an automated screening process to routinely test 10 chiral supercritical fluid chromatography (SFC) methods - five columns combined with two co-solvents - as part of a chiral separation lab workflow. Proprietary ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone 

      Jähne, Evelyn A.; Eigenmann, Daniela E.; Moradi-Afrapoli, Fahimeh; Verjee, Sheela; Butterweck, Veronika; Hebeisen, Simon; Hettich, Timm; Schlotterbeck, Götz; Smiesko, Martin; Hamburger, Matthias; Oufir, Mouhssin (2016)
      Planta Medica
      Tryptanthrin and (E,​Z)​-​3-​(4-​hydroxy-​3,​5-​dimethoxybenzylidene)​indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-​inflammatory and antiallergic alkaloids, and shown to inhibit COX-​2, ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Effect of a chronic Intake of the natural sweeteners Xylitol and Erythritol on glucose absorption in humans with obesity 

      Bordier, Valentine; Teysseire, Fabienne; Schlotterbeck, Götz; Beglinger, Christoph; Meyer-Gerspach, Anne-Christin; Wölnerhanssen, Bettina; Senner, Frank (2021-11-05)
      In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute in- gestion reduces ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients 

      Kohler, Reto; Anugraham, Merrina; Nunez Lopez, Monica; Xiao, Christina; Schoetzau, Andreas; Hettich, Timm; Schlotterbeck, Götz; Fedier, André; Jacob, Francis; Heinzelmann-Schwarz, Viola (2016-07-12)
      Bisecting GlcNAc on N-glycoproteins is described in E-cadherin-, EGF-, Wnt- and integrin- cancer-associated signaling pathways. However, the mechanisms regulating bisecting GlcNAc expression are not clear. Bisecting ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Extended and Fully Automated Newborn Screening Method for Mass Spectrometry Detection 

      Gaugler, Stephan; Rykl, Jana; Wagner, Irene; von Däniken, Tamara; Fingerhut, Ralph; Schlotterbeck, Götz (2017-12)
      International Journal of Neonatal Screening
      A new and fully automated newborn screening method for mass spectrometry was introduced in this paper. Pathological relevant amino acids, acylcarnitines, and certain steroids are detected within 4 min per sample. Each ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding 

      Zabela, Volha; Hettich, Timm; Schlotterbeck, Götz; Wimmer, Laurin; Mihovilovic D., Marko; Guillet, Fabrice; Belkacem, Bouaita; Shevchenko, Bénédicte; Hamburger, Matthias; Oufir, Mouhssin (2017-12)
      Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
      In a screening of natural products for allosteric modulators of GABAA receptors (γ-aminobutyric acid type A receptor), piperine was identified as a compound targeting a benzodiazepine-independent binding site. Given that ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Metabolic Profiling 

      Berchtold, Christian; Hettich, Timm; Schlotterbeck, Götz; Senner, Frank (2015)
      GIT Labor Fachzeitschrift
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Metabolomic Abnormalities in Serum from Untreated and Treated Dogs with Hyper- and Hypoadrenocorticism 

      Imbery, Carolin Anna; Dieterle, Frank; Ottka, Claudia; Weber, Corinna; Müller, Elisabeth; Lohi, Hannes; Giger, Urs; Schlotterbeck, Götz (2022-04-09)
      The adrenal glands play a major role in metabolic processes, and both excess and insufficient serum cortisol concentrations can lead to serious metabolic consequences. Hyper- and hypoadrenocorticism represent a diagnostic ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
    • Metabolomic serum abnormalities in dogs with hepatopathies 

      Imbery, Carolin A.; Dieterle, Frank; Ottka, Claudia; Weber, Corinna; Müller, Elisabeth; Lohi, Hannes; Giger, Urs; Schlotterbeck, Götz (2022-03-29)
      Scientific Reports
      Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic ...
      01A - Beitrag in wissenschaftlicher Zeitschrift
    • Method Development For High-Throughput LC/MS With Minimized Carry Over 

      Schlotterbeck, Götz (2015)
      06 - Präsentation
    • Minimizing carry-over for high throughput analysis 

      Schlotterbeck, Götz; Berchtold, Christian; Böhm, Günter; Reto, Bolliger (2015)
      International Symposium on High Performance Liquid Phase Separations (HPLC)
      04 - Beitrag Sammelband oder Konferenzschrift
    • Novel Analytical Workflow for Comprehensive 

      Hettich, Timm; Schlotterbeck, Götz (2015)
      01 - Zeitschriftenartikel, Journalartikel oder Magazin
    • Validation of a simple and sensitive method for the quantification of the bile acid 7?-Hydroxy-4-cholesten-3-one (C4), (Poster) 

      Berchtold, Christian; Schlotterbeck, Götz; Bovet, Cédric; Prost, Jean-Christophe; Grob, Christian (2015)
      06 - Präsentation
    • Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study 

      Cuenod, Aline; Wüthrich, Daniel; Seth-Smith, Helena; Ott, Chantal; Gehringer, Christian; Foucaul, Frederic; Mouchet, Roxanne; Kassim, Ali; Revathi, Gunturu; Vogt, Deborah; von Felten, Stefanie; Bassetti, Stefano; Tschudin-Sutter, Sarah; Hettich, Timm; Schlotterbeck, Götz; Homberger, Christina; Casanova, Carlo; Moran-Gilad, Jakob; Sagi, Orli; Rodriguez-Sanchez, Belen; Müller, Franco; Aerni, Martina; Gaia, Valeria; van Dessel, Helke; Kampinga, Greetje; Müller, Claudia; Daubenberger, Claudia; Pflüger, Valentin; Egli, Adrian (2021)
      Genome Medicine
      Background Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin