Auflistung nach Autor/Autorin "Oufir, Mouhssin"
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Caco-2 Permeability Studies and In Vitro hERG Liability Assessment of Tryptanthrin and Indolinone
(2016)Planta MedicaTryptanthrin and (E,Z)-3-(4-hydroxy-3,5-dimethoxybenzylidene)indolinone (indolinone) were recently isolated from Isatis tinctoria as potent anti-inflammatory and antiallergic alkaloids, and shown to inhibit COX-2, ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Development and full validation of an UPLC-MS/MS method for the quantification of the plant-derived alkaloid indirubin in rat plasma
(2016)Journal of Pharmaceutical and Biomedical AnalysisAn UPLC-MS/MS method for the quantification of indirubin in lithium heparinized rat plasma was developed and validated according to current international guidelines. Indirubin was extracted from rat plasma by using Waters ...01A - Beitrag in wissenschaftlicher Zeitschrift -
GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding
(2017-12)Journal of Chromatography BIn a screening of natural products for allosteric modulators of GABAA receptors (γ-aminobutyric acid type A receptor), piperine was identified as a compound targeting a benzodiazepine-independent binding site. Given that ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Pharmacokinetics and in vitro blood-brain barrier screening of the plant-derived alkaloid tryptanthrin
(2016)Planta MedicaThe indolo[2,1-b]quinazoline alkaloid tryptanthrin was previously identified as a potent anti-inflammatory compound with a unique pharmacological profile. It is a potent inhibitor of cyclooxygenase-2, 5-lipooxygenase-catalyzed ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Pharmacokinetics of dietary kaempferol and its metabolite 4-hydroxyphenylacetic acid in rats
(2016-12)FitoterapiaSCOPE: Kaempferol is a major flavonoid in the human diet and in medicinal plants. The compound exerts anxiolytic activity when administered orally in mice, while no behavioural changes were observed upon intraperitoneal ...01A - Beitrag in wissenschaftlicher Zeitschrift -
Validation of UHPLC–MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies
(2016-09-05)Journal of Pharmaceutical and Biomedical Analysis01A - Beitrag in wissenschaftlicher Zeitschrift