Auflistung nach Autor/Autorin "Koehl, Niklas"
Anzeige der Einträge 1-10 von 10
-
Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
(2018-07)Journal of Pharmacy and PharmacologyObjectives Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review
(2018-05)Journal of Pharmacy and PharmacologyObjectives Supersaturating formulations hold great promise for delivery of poorly soluble active pharmaceutical ingredients (APIs). To profit from supersaturating formulations, precipitation is hindered with precipitation ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Chase Dosing of Lipid Formulations to Enhance Oral Bioavailability of Nilotinib in Rats
(2020-06-10)Pharmaceutical ResearchConclusion: Chase dosed LBF enhanced the in vivo bioavailability of nilotinib. Long chain lipids showed superior performance compared to medium chain lipids. Chase dosing appeared to prolong the absorption phase of the ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Exploring the Impact of Surfactant Type and Digestion: Highly Digestible Surfactants Improve Oral Bioavailability of Nilotinib
(2020-09-08)Molecular PharmaceuticsThe scientific rationale for selection of the surfactant type during oral formulation development requires an in-depth understanding of the interplay between surfactant characteristics and biopharmaceutical factors. ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
In Silico, In Vitro, and In Vivo evaluation of precipitation inhibitors in supersaturated lipid-based formulations of venetoclax
(2021-04-23)Molecular PharmaceuticsThe concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilic salts and lipid-based formulations for bridging the food effect gap of venetoclax
(2022-01)Pharmaceutics, Drug Delivery and Pharmaceutical TechnologyLipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches | a PEARRL review
(2019-04)Journal of Pharmacy and Pharmacology01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review
(2018-08)Journal of Pharmacy and PharmacologyObjectives This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
New Insights into Using Lipid Based Suspensions for 'Brick Dust' Molecules: Case Study of Nilotinib
(2019-02-22)Pharmaceutical ResearchPurposeLipid suspensions have been shown to be a suitablebio-enabling formulation approach for highly lipophilic or‘grease ball’drug molecules, but studies on‘brick dust’drugsare lacking. This study explored the utility ...01 - Zeitschriftenartikel, Journalartikel oder Magazin -
Supersaturated Lipid-Based Formulations to Enhance the Oral Bioavailability of Venetoclax
(2020-06-18)PharmaceuticsIncreasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. ...01 - Zeitschriftenartikel, Journalartikel oder Magazin
