Auflistung nach Autor/Autorin "Henze, Laura"

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    • In Silico, In Vitro, and In Vivo evaluation of precipitation inhibitors in supersaturated lipid-based formulations of venetoclax 

      Koehl, Niklas; Henze, Laura; Bennett-Lenane, Harriett; Faisal, Waleed; Price, Daniel J.; Holm, Rene; Kuentz, Martin; Griffin, Brendan (2021-04-23)
      Molecular Pharmaceutics
      The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin

    • Lipophilic salts and lipid-based formulations for bridging the food effect gap of venetoclax 

      Koehl, Niklas; Henze, Laura; Holm, Rene; Kuentz, Martin; Keating, John; De Vijlder, Thomas; Marx, Andreas; Griffin, Brendan (2022-01)
      Pharmaceutics, Drug Delivery and Pharmaceutical Technology
      Lipid based formulations (LBF) have shown to overcome food dependent bioavailability for some poorly water-soluble drugs. However, the utility of LBFs can be limited by low dose loading due to a low drug solubility in LBF ...
      01 - Zeitschriftenartikel, Journalartikel oder Magazin